Yogic Neti-Kriya Using Povidone Iodine: Can it have a Preventive Role Against SARS-CoV-2 Infection Gateway?

Autor: Sarma P; Department of Pharmacology, PGIMER, Chandigarh, Pin 160012 India., Bhattacharyya A; Department of Ophthalmology, Government Medical College and Hospital, Sector 32, Chandigarh, India., Prakash A; Department of Pharmacology, PGIMER, Chandigarh, Pin 160012 India., Kaur H; Department of Pharmacology, PGIMER, Chandigarh, Pin 160012 India., Prajapat M; Department of Pharmacology, PGIMER, Chandigarh, Pin 160012 India., Borah M; Department of Pharmacology, Gauhati Medical College and Hospital, Guwahati, Assam India., Kumar S; Department of Pharmacology, PGIMER, Chandigarh, Pin 160012 India., Bansal S; Department of Pharmacology, PGIMER, Chandigarh, Pin 160012 India., Sharma S; Department of Pharmacology, PGIMER, Chandigarh, Pin 160012 India., Kaur G; Department of Pharmacology, PGIMER, Chandigarh, Pin 160012 India., Kumar H; Department of Pharmacology, PGIMER, Chandigarh, Pin 160012 India., Sharma DJ; Department of Internal Medicine, Silchar Medical College and Hospital, Silchar, Assam India., Das KK; Department of Anaesthesiology, Assam Medical College and Hospital, Dibrugarh, Assam India., Avti P; Department of Biophysics, PGIMER, Chandigarh, India., Medhi B; Department of Pharmacology, PGIMER, Chandigarh, Pin 160012 India.
Jazyk: angličtina
Zdroj: Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India [Indian J Otolaryngol Head Neck Surg] 2022 Oct; Vol. 74 (Suppl 2), pp. 3186-3192. Date of Electronic Publication: 2021 Oct 17.
DOI: 10.1007/s12070-021-02885-2
Abstrakt: During this COVID-19 pandemic, except steroid, none of the therapeutic measures have showed any evidence of efficacy. Traditionally jala-neti using lukewarm salted water remains a yogic way of maintaining upper airway hygiene. Saline irrigation decreases the concentration of inflammatory mediators (e.g. histamine, leukotriene etc.) in nasal secretions, reduces the severity and frequency of sinusitis, reduce need of antibiotic therapy and restores competency of nasal mucosa. Jala-neti is an integral part of six cleansing techniques of yogic kriyas practised in India since thousands of years. Jala-neti can clean the upper airways, prevents colonization of infectious agents, removes foreign bodies, prevents stasis of mucous and subsequently enhances the drainage of paranasal sinuses and maintain health. Regular practice of Jala neti improves nasal symptoms and overall health status of patients with sinusitis. Jala-neti sample can even be used for COVID-19 diagnosis. Povidone iodine (PVP-I) has been utilized as a time tested antimicrobial agent with broad spectrum coverage against wide range of bacteria and viruses. Anti-SARS-CoV-2 action of PVP-I was seen at a concentration as low as 0.45% . PVP-I is generally well tolerated upto 5%, however nasal ciliotoxicity is reported at this concentration, however, this toxicity is not reported with lower concentrations(1.25% and 0.5%). So, theoretically, by using neti-kriya with povidone iodine (0.5-1%) as irrigation solution can combine and enhance the protection against COVID-19 and this can be an important armor in the fight against COVID-19. However, this hypothesis needs to be validated in real life clinical trial scenario before implementing.
(© Association of Otolaryngologists of India 2021.)
Databáze: MEDLINE
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