| Autor: |
Finch RG, Craddock C, Kelly J, Deaney NB |
| Jazyk: |
angličtina |
| Zdroj: |
The Journal of antimicrobial chemotherapy [J Antimicrob Chemother] 1986 Dec; Vol. 18 Suppl E, pp. 103-7. |
| DOI: |
10.1093/jac/18.supplement_e.103 |
| Abstrakt: |
Six patients, aged between 68 and 83 years, with glomerular filtration rates (GFR) between 31 and 80 ml/min received imipenem/cilastatin as treatment for acute lower respiratory tract infection. A combination of 500 mg of both agents was administered, 6-hourly, intravenously over 30 min. After a minimum of four doses, blood specimens were obtained for assay of imipenem and cilastatin concentrations by HPLC. Pharmacokinetic parameters were calculated from the results. The mean half life was 1.6 h for imipenem and 2.1 h for cilastatin, values similar to those reported for patients with moderate renal impairment. Elimination constant, clearance and AUC significantly correlated with GFR but not with age. No accumulation was observed. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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