Association Between 25(OH)Vitamin D, HbA1c and Albuminuria in Diabetes Mellitus: Data From a Population-Based Study (VIDAMAZON).

Autor:	Felício JS; Endocrinology Division, University Hospital João de Barros Barreto, Federal University of Pará, Belém, Brazil., de Rider Britto HA; Endocrinology Division, University Hospital João de Barros Barreto, Federal University of Pará, Belém, Brazil., Cortez PC; Endocrinology Division, University Hospital João de Barros Barreto, Federal University of Pará, Belém, Brazil., de Souza Resende F; Endocrinology Division, University Hospital João de Barros Barreto, Federal University of Pará, Belém, Brazil., de Lemos MN; Endocrinology Division, University Hospital João de Barros Barreto, Federal University of Pará, Belém, Brazil., de Moraes LV; Endocrinology Division, University Hospital João de Barros Barreto, Federal University of Pará, Belém, Brazil., de Aquino VT; Endocrinology Division, University Hospital João de Barros Barreto, Federal University of Pará, Belém, Brazil., de Souza Parente F; Endocrinology Division, University Hospital João de Barros Barreto, Federal University of Pará, Belém, Brazil., de Queiroz NNM; Endocrinology Division, University Hospital João de Barros Barreto, Federal University of Pará, Belém, Brazil., Abrahão Neto JF; Endocrinology Division, University Hospital João de Barros Barreto, Federal University of Pará, Belém, Brazil., de Alcântara AL; Endocrinology Division, University Hospital João de Barros Barreto, Federal University of Pará, Belém, Brazil., da Silva WM; Endocrinology Division, University Hospital João de Barros Barreto, Federal University of Pará, Belém, Brazil., de Souza Neto NJK; Endocrinology Division, University Hospital João de Barros Barreto, Federal University of Pará, Belém, Brazil., Freire Piani PP; Endocrinology Division, University Hospital João de Barros Barreto, Federal University of Pará, Belém, Brazil., de Souza ÍJA; Endocrinology Division, University Hospital João de Barros Barreto, Federal University of Pará, Belém, Brazil., Silva LSD; Endocrinology Division, University Hospital João de Barros Barreto, Federal University of Pará, Belém, Brazil., de Oliveira MCNI; Endocrinology Division, University Hospital João de Barros Barreto, Federal University of Pará, Belém, Brazil., Said NM; Endocrinology Division, University Hospital João de Barros Barreto, Federal University of Pará, Belém, Brazil., Nascimento de Lemos G; Endocrinology Division, University Hospital João de Barros Barreto, Federal University of Pará, Belém, Brazil., de Melo FTC; Endocrinology Division, University Hospital João de Barros Barreto, Federal University of Pará, Belém, Brazil., Gomes DL; Endocrinology Division, University Hospital João de Barros Barreto, Federal University of Pará, Belém, Brazil., Contente Braga de Souza AC; Endocrinology Division, University Hospital João de Barros Barreto, Federal University of Pará, Belém, Brazil., de Sá Oliveira Dos Reis M; Endocrinology Division, University Hospital João de Barros Barreto, Federal University of Pará, Belém, Brazil., Leal VSG; Endocrinology Division, University Hospital João de Barros Barreto, Federal University of Pará, Belém, Brazil., Lobato IJC; Endocrinology Division, University Hospital João de Barros Barreto, Federal University of Pará, Belém, Brazil., Felício KM; Endocrinology Division, University Hospital João de Barros Barreto, Federal University of Pará, Belém, Brazil.
Jazyk:	angličtina
Zdroj:	Frontiers in endocrinology [Front Endocrinol (Lausanne)] 2021 Oct 07; Vol. 12, pp. 723502. Date of Electronic Publication: 2021 Oct 07 (Print Publication: 2021).
DOI:	10.3389/fendo.2021.723502
Abstrakt:	Background: The effect of glycemic control on diabetic kidney disease (DKD) is well known. Recent evidence has suggested that Vitamin D (VD) may have a nephroprotective effect in diabetes, but the relationship between VD, glycemic control, and albuminuria has yet to be clarified. Objective: Evaluate the relationship between 25-hydroxy-vitamin D [25(OH)D], HbA1c, and albuminuria in Diabetes Mellitus (DM). Patients and Methods: Cross-sectional study with 1576 individuals with DM who had 25(OH)D, HbA1c, and albuminuria levels measured. Patients with abnormal creatinine levels were excluded, in order to avoid interference on VD levels by impaired kidney function. Results: Patients with HbA1c ≥7% had lower 25(OH)D when compared to patients with HbA1c <7% (29.7 ± 10.2 vs 28.1 ± 9.9 ng/ml, p = 0.003) and 25(OH)D levels seems to predict 1.5% of HbA1c behavior. The 25(OH)D concentrations in patients with normoalbuminuria were higher than the levels observed in those with micro or macroalbuminuria (29.8 ± 9.0 vs 26.8 ± 8.6 and 25.1 ± 7.6, respectively, p = 0.001), patients who had 25(OH)D <20 ng/ml and 25(OH)D <30 ng/ml were at a higher risk of presenting albuminuria [OR = 2.8 (95% CI = 1.6 - 4.9), p<0.001, and OR = 2.1 (95% CI = 1.3 - 4.6), p<0.001, respectively]. In our regression model, albuminuria was influenced by HbA1c (r² = 0.076, p<0.00001) and 25(OH)D (r² = 0.018, p = 0.002) independently. Conclusion: Our study found an association between vitamin D levels, HbA1c and DKD. Additionally, our data suggest that the association between urinary albumin excretion and vitamin D levels is independent of glycemic control in patients with diabetes. Even though our patients presented normal creatinine levels, it is necessary further prospective studies to confirm if this association precedes or not the loss of renal function. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2021 Felício, de Rider Britto, Cortez, de Souza Resende, de Lemos, de Moraes, de Aquino, de Souza Parente, de Queiroz, Abrahão Neto, de Alcântara, da Silva, de Souza Neto, Freire Piani, de Souza, Silva, de Oliveira, Said, Nascimento de Lemos, de Melo, Gomes, Contente Braga de Souza, de Sá Oliveira dos Reis, Leal, Lobato and Felício.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu