Granulocyte Transfusion: Clinical Updates and a Practical Approach to Transfusion.
| Autor: | Cohen T; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA; Department of Transfusion Medicine, New York-Presbyterian Hospital, New York, NY, USA., Simmons SC; Butterworth Blood Bank, Department of Pathology, Michigan Pathology Specialists, Spectrum Health Hospitals, Grand Rapids, MI, USA., Pham HP; National Marrow Donor Program, Seattle, WA, USA., Staley EM; Department of Laboratory Medicine and Pathology, University of Washington, Seattle, WA, USA. Electronic address: estaley@uw.edu. |
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| Jazyk: | angličtina |
| Zdroj: | Clinics in laboratory medicine [Clin Lab Med] 2021 Dec; Vol. 41 (4), pp. 647-657. Date of Electronic Publication: 2021 Sep 29. |
| DOI: | 10.1016/j.cll.2021.07.007 |
| Abstrakt: | Neutrophils are an integral component of the innate immune system and key regulators of cell-mediated defense against bacterial and fungal pathogens. The potential of granulocyte transfusions has been investigated to temporarily replenish innate immune function to prevent and/or treat infections in patients with severe neutropenia or neutrophil dysfunction. However, evidence has been largely theoretical, experimental, and/or inconclusive. Clinical efficacy has yet to be confirmed by large-scale randomized controlled clinical trials. Performing such trials has been hampered by low granulocyte collection yield and poor patient accrual. We provide a practical summary of the current literature surrounding the practice of granulocyte transfusion. Competing Interests: Disclosure H.P. Pham is a consultant for Sanofi and a speaker for Alexion. All other authors declared no conflict of interest. (Copyright © 2021 Elsevier Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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