Potential role of marine species-derived bioactive agents in the management of SARS-CoV-2 infection.

Autor: Asif M; Department of Pharmacology, Faculty of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur, 63100, Punjab, Pakistan., Saleem M; Punjab University College of Pharmacy, University of the Punjab, Lahore, 54000, Punjab, Pakistan., Yaseen HS; Faculty of Pharmaceutical Sciences, Government College University Faisalabad, Faisalabad, 38000, Punjab, Pakistan., Yehya AH; Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, Penang, 11800, Malaysia., Saadullah M; Faculty of Pharmaceutical Sciences, Government College University Faisalabad, Faisalabad, 38000, Punjab, Pakistan., Zubair HM; Department of Pharmacology, Faculty of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur, 63100, Punjab, Pakistan., Oon CE; Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, Penang, 11800, Malaysia., Khaniabadi PM; Department of Radiology & Molecular Imaging, College of Medicine & Health Sciences, Sultan Qaboos University, PO. Box 35, 123, Al Khod, Muscat, Oman., Khalid SH; Faculty of Pharmaceutical Sciences, Government College University Faisalabad, Faisalabad, 38000, Punjab, Pakistan., Khan IU; Faculty of Pharmaceutical Sciences, Government College University Faisalabad, Faisalabad, 38000, Punjab, Pakistan., Mahrukh; Faculty of Pharmaceutical Sciences, Government College University Faisalabad, Faisalabad, 38000, Punjab, Pakistan.
Jazyk: angličtina
Zdroj: Future microbiology [Future Microbiol] 2021 Nov; Vol. 16, pp. 1289-1301. Date of Electronic Publication: 2021 Oct 25.
DOI: 10.2217/fmb-2021-0024
Abstrakt: COVID-19, caused by the SARS-CoV-2 outbreak, has resulted in a massive global health crisis. Bioactive molecules extracted or synthesized using starting material obtained from marine species, including griffithsin, plitidepsin and fingolimod are in clinical trials to evaluate their anti-SARS-CoV-2 and anti-HIV efficacies. The current review highlights the anti-SARS-CoV-2 potential of marine-derived phytochemicals explored using in silico , in vitro  and in vivo models. The current literature suggests that these molecules have the potential to bind with various key drug targets of SARS-CoV-2. In addition, many of these agents have anti-inflammatory and immunomodulatory potentials and thus could play a role in the attenuation of COVID-19 complications. Overall, these agents may play a role in the management of COVID-19, but further preclinical and clinical studies are still required to establish their role in the mitigation of the current viral pandemic.
Databáze: MEDLINE
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