Wide-Field Calcium Imaging of Dynamic Cortical Networks during Locomotion.

Autor:	West SL; Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA.; Graduate Program in Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA., Aronson JD; Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA., Popa LS; Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA., Feller KD; Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA.; Union College Biological Sciences Department, Schenectady, NY 12308, USA., Carter RE; Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA., Chiesl WM; Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA., Gerhart ML; Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA., Shekhar AC; Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA., Ghanbari L; Department of Mechanical Engineering, University of Minnesota, Minneapolis, MN 55455, USA., Kodandaramaiah SB; Graduate Program in Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA.; Department of Mechanical Engineering, University of Minnesota, Minneapolis, MN 55455, USA.; Department of Biomedical Engineering, University of Minnesota, Minneapolis, MN 55455, USA., Ebner TJ; Department of Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA.; Graduate Program in Neuroscience, University of Minnesota, Minneapolis, MN 55455, USA.
Jazyk:	angličtina
Zdroj:	Cerebral cortex (New York, N.Y. : 1991) [Cereb Cortex] 2022 Jun 07; Vol. 32 (12), pp. 2668-2687.
DOI:	10.1093/cercor/bhab373
Abstrakt:	Motor behavior results in complex exchanges of motor and sensory information across cortical regions. Therefore, fully understanding the cerebral cortex's role in motor behavior requires a mesoscopic-level description of the cortical regions engaged, their functional interactions, and how these functional interactions change with behavioral state. Mesoscopic Ca2+ imaging through transparent polymer skulls in mice reveals elevated activation of the dorsal cerebral cortex during locomotion. Using the correlations between the time series of Ca2+ fluorescence from 28 regions (nodes) obtained using spatial independent component analysis (sICA), we examined the changes in functional connectivity of the cortex from rest to locomotion with a goal of understanding the changes to the cortical functional state that facilitate locomotion. Both the transitions from rest to locomotion and from locomotion to rest show marked increases in correlation among most nodes. However, once a steady state of continued locomotion is reached, many nodes, including primary motor and somatosensory nodes, show decreases in correlations, while retrosplenial and the most anterior nodes of the secondary motor cortex show increases. These results highlight the changes in functional connectivity in the cerebral cortex, representing a series of changes in the cortical state from rest to locomotion and on return to rest. (© The Author(s) 2021. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
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