Blood derived extracellular vesicles as regenerative medicine therapeutics.

Autor: de Boer C; Cardiovascular Research Unit, Division of Cardiothoracic Surgery, University of Cape Town, Observatory, South Africa., Davies NH; Cardiovascular Research Unit, Division of Cardiothoracic Surgery, University of Cape Town, Observatory, South Africa. Electronic address: neil.davies@uct.ac.za.
Jazyk: angličtina
Zdroj: Biochimie [Biochimie] 2022 May; Vol. 196, pp. 203-215. Date of Electronic Publication: 2021 Oct 21.
DOI: 10.1016/j.biochi.2021.10.009
Abstrakt: The regenerative promise of nanosized extracellular vesicles (EVs) secreted by cells is widely explored. Recently, the capacity of EVs purified from blood to elicit regenerative effect has begun to be evaluated. Blood might be a readily available source of EVs, avoiding need for extensive cell culturing, but there are specific issues that complicate use of the biofluid in this area. We assess the evidence for blood containing regenerative material, progress made towards delivering blood derived EVs as regenerative therapeutics, difficulties that relate to the complexity of blood and the promise of hydrogel-based delivery of EVs.
Competing Interests: Declaration of competing interest The authors declare no conflicts of interest.
(Copyright © 2021 Elsevier B.V. and Société Française de Biochimie et Biologie Moléculaire (SFBBM). All rights reserved.)
Databáze: MEDLINE
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