Relapsing-remitting and secondary-progressive multiple sclerosis patients differ in decoding others' emotions by their eyes.

Autor: Argento O; Neurology and Neurorehabilitation Unit, Santa Lucia Foundation, Scientific Institute for Research and Health Care, Rome, Italy., Spanò B; Neuroimaging Unit, Santa Lucia Foundation, Scientific Institute for Research and Health Care, Rome, Italy., Serra L; Neuroimaging Unit, Santa Lucia Foundation, Scientific Institute for Research and Health Care, Rome, Italy., Incerti CC; Neurology and Neurorehabilitation Unit, Santa Lucia Foundation, Scientific Institute for Research and Health Care, Rome, Italy., Bozzali M; Rita Levi Montalcini Department of Neuroscience,, University of Turin, Turin, Italy.; Department of Neuroscience, Brighton and Sussex Medical School, University of Sussex, Brighton, UK., Caltagirone C; Scientific Direction, Santa Lucia Foundation, Scientific Institute for Research and Health Care, Rome, Italy., Francia A; Department of Neurological Sciences, Sapienza University of Rome, Rome, Italy., Fratino M; Department of Neurological Sciences, Sapienza University of Rome, Rome, Italy., Nocentini U; Neurology and Neurorehabilitation Unit, Santa Lucia Foundation, Scientific Institute for Research and Health Care, Rome, Italy.; Department of Clinical Sciences and Translational Medicine, Tor Vergata University of Rome, Rome, Italy., Piacentini C; Neurology and Neurorehabilitation Unit, Santa Lucia Foundation, Scientific Institute for Research and Health Care, Rome, Italy., Quartuccio ME; Department of Neurological Sciences, Sapienza University of Rome, Rome, Italy., Pisani V; Neurology and Neurorehabilitation Unit, Santa Lucia Foundation, Scientific Institute for Research and Health Care, Rome, Italy.
Jazyk: angličtina
Zdroj: European journal of neurology [Eur J Neurol] 2022 Feb; Vol. 29 (2), pp. 505-514. Date of Electronic Publication: 2021 Nov 04.
DOI: 10.1111/ene.15155
Abstrakt: Background and Purpose: Difficulties in emotion processing and social cognition identified in multiple sclerosis (MS) patients have a potential impact on their adaptation to the social environment. We aimed to explore the neural correlates of emotion recognition in MS and possible differences between relapsing-remitting MS (RRMS) and secondary progressive MS (SPMS) patients by the Reading the Mind in the Eyes test (RMEt).
Methods: A total of 43 MS patients (27 RRMS, 16 SPMS) and 25 matched healthy controls (HC) underwent clinical assessments, RMEt, and a high-resolution T1-weighted 3-T magnetic resonance imaging (MRI) scan. The number of correct answers on the RMEt was compared between groups. T1-weighted volumes were processed according to an optimized voxel-based morphometry (VBM) protocol to obtain gray matter (GM) maps. Voxelwise analyses were run to assess potential associations between RMEt performance and regional GM volumes.
Results: Taken altogether, MS patients reported significantly lower performance on the RMEt compared to HC. When dividing the patients into those with RRMS and those with SPMS, only the latter group was found to perform significantly worse than HC on the RMEt. VBM analysis revealed significant association between RMEt scores and GM volumes in several cortical (temporoparieto-occipital cortex) and subcortical (hippocampus, parahippocampus, and basal ganglia) brain regions, and in the cerebellum in SPMS patients only.
Conclusions: Results suggest that, in addition to other clinical differences between RRMS and SPMS, the ability to recognize others' emotional states may be affected in SPMS more significantly than RRMS patients. This is supported by both behavioral and MRI data.
(© 2021 European Academy of Neurology.)
Databáze: MEDLINE
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