| Autor: |
Kambiré DA; UPR de Chimie Organique, Département de Mathématiques, Physique et Chimie, UFR des Sciences Biologiques, Université Péléforo Gon Coulibaly, Korhogo BP 1328, Côte d'Ivoire., Boti JB; Laboratoire de Constitution et Réaction de la Matière, UFR-SSMT, Université Félix Houphouët-Boigny, Abidjan BP 1328, Côte d'Ivoire., Kablan ACL; UPR de Chimie Organique, Département de Mathématiques, Physique et Chimie, UFR des Sciences Biologiques, Université Péléforo Gon Coulibaly, Korhogo BP 1328, Côte d'Ivoire., Ballo D; Laboratoire de Constitution et Réaction de la Matière, UFR-SSMT, Université Félix Houphouët-Boigny, Abidjan BP 1328, Côte d'Ivoire., Paoli M; Laboratoire Sciences Pour l'Environnement, Université de Corse-CNRS, UMR 6134 SPE, Route des Sanguinaires, 20000 Ajaccio, France., Brunini V; Laboratoire Sciences Pour l'Environnement, Université de Corse-CNRS, UMR 6134 SPE, Route des Sanguinaires, 20000 Ajaccio, France., Tomi F; Laboratoire Sciences Pour l'Environnement, Université de Corse-CNRS, UMR 6134 SPE, Route des Sanguinaires, 20000 Ajaccio, France. |
| Abstrakt: |
The chemical variability and the in vitro anti-inflammatory activity of the leaf essential oil from Ivorian Isolona dewevrei were investigated for the first time. Forty-seven oil samples were analyzed using a combination of CC, GC(RI), GC-MS and 13 C-NMR, thus leading to the identification of 113 constituents (90.8-98.9%). As the main components varied drastically from sample to sample, the 47 oil compositions were submitted to hierarchical cluster and principal components analyses. Three distinct groups, each divided into two subgroups, were evidenced. Subgroup I-A was dominated by ( Z )-β-ocimene, β-eudesmol, germacrene D and ( E )-β-ocimene, while (10βH)-1β,8β-oxido-cadina-4-ene, santalenone, trans -α-bergamotene and trans -β-bergamotene were the main compounds of Subgroup I-B. The prevalent constituents of Subgroup II-A were germacrene B, ( E )-β-caryophyllene, (5αH,10βMe)-6,12-oxido-elema-1,3,6,11(12)-tetraene and γ-elemene. Subgroup II-B displayed germacrene B, germacrene D and ( Z )-β-ocimene as the majority compounds. Germacrene D was the most abundant constituent of Group III, followed in Subgroup III-A by ( E )-β-caryophyllene, (10βH)-1β,8β-oxido-cadina-4-ene, germacrene D-8-one, and then in Subgroup III-B by ( Z )-β-ocimene and ( E )-β-ocimene. The observed qualitative and quantitative chemical variability was probably due to combined factors, mostly phenology and season, then harvest site to a lesser extent. The lipoxygenase inhibition by a leaf oil sample was also evaluated. The oil IC 50 (0.020 ± 0.005 mg/mL) was slightly higher than the non-competitive lipoxygenase inhibitor NDGA IC 50 (0.013 ± 0.003 mg/mL), suggesting a significant in vitro anti-inflammatory potential. |
