A Seroprevalence Study of Anti-SARS-CoV-2 Antibodies in Patients with Inflammatory Bowel Disease during the Second Wave of the COVID-19 Pandemic in Italy.

Autor:	Di Ruscio M; IBD Unit, IRCCS Sacro Cuore Don Calabria Hospital, 37024 Negrar di Valpolicella (VR), Italy., Lunardi G; Medical Analysis Laboratory, IRCCS Sacro Cuore Don Calabria Hospital, 37024 Negrar di Valpolicella (VR), Italy., Buonfrate D; Department of Infectious, Tropical Diseases and Microbiology, IRCCS Sacro Cuore Don Calabria Hospital, 37024 Negrar di Valpolicella (VR), Italy., Gobbi F; Department of Infectious, Tropical Diseases and Microbiology, IRCCS Sacro Cuore Don Calabria Hospital, 37024 Negrar di Valpolicella (VR), Italy., Bertoli G; Department of Infectious, Tropical Diseases and Microbiology, IRCCS Sacro Cuore Don Calabria Hospital, 37024 Negrar di Valpolicella (VR), Italy., Piccoli D; Medical Analysis Laboratory, IRCCS Sacro Cuore Don Calabria Hospital, 37024 Negrar di Valpolicella (VR), Italy., Conti A; Medical Analysis Laboratory, IRCCS Sacro Cuore Don Calabria Hospital, 37024 Negrar di Valpolicella (VR), Italy., Geccherle A; IBD Unit, IRCCS Sacro Cuore Don Calabria Hospital, 37024 Negrar di Valpolicella (VR), Italy., Variola A; IBD Unit, IRCCS Sacro Cuore Don Calabria Hospital, 37024 Negrar di Valpolicella (VR), Italy.
Jazyk:	angličtina
Zdroj:	Medicina (Kaunas, Lithuania) [Medicina (Kaunas)] 2021 Oct 01; Vol. 57 (10). Date of Electronic Publication: 2021 Oct 01.
DOI:	10.3390/medicina57101048
Abstrakt:	Background and Objectives: Studies have shown a lower prevalence of anti-SARS-CoV-2 antibodies in patients with inflammatory bowel disease (IBD), including amongst those receiving biological therapy. Aims were to determine the seroprevalence of anti-SARS-CoV-2 antibodies in IBD patients and to assess any association between seropositivity and IBD characteristics. Materials and Methods: Serum from adult IBD patients was prospectively collected between December 2020 and January 2021 and analyzed for anti-SARS-CoV-2 antibodies. Information about IBD characteristics and SARS-CoV-2 exposure risk factors was collected and analyzed. Serum from non-IBD healthcare workers formed the control group. Results: 311 IBD patients on biologics and 75 on mesalazine were enrolled. Ulcerative colitis (UC) extension ( p < 0.001), Crohn's disease (CD) phenotype ( p = 0.009) and use of concomitant corticosteroids ( p < 0.001) were significantly different between the two IBD groups. Overall seroprevalence among IBD patients was 10.4%. The control group showed a prevalence of 13.0%, not significantly different to that of IBD patients ( p = 0.145). Only a close contact with SARS-CoV-2 positive individuals and the use of non-FFP2 masks were independently associated with a higher likelihood of seropositivity amongst IBD patients. Conclusion: In IBD patients, the prevalence of anti-SARS-CoV-2 antibodies is not determined by their ongoing treatment. Disease-related characteristics are not associated with a greater risk of antibody seropositivity.
Databáze:	MEDLINE
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