A Prospective Study of CPAP Therapy in Relation to Cardiovascular Outcome in a Cohort of Romanian Obstructive Sleep Apnea Patients.

Autor:	Chetan IM; Department of Pneumology, 'Iuliu Hatieganu' University of Medicine and Pharmacy, 400332 Cluj-Napoca, Romania.; Heart Institute 'Nicolae Stancioiu', 400001 Cluj-Napoca, Romania., Maierean AD; Department of Pneumology, 'Iuliu Hatieganu' University of Medicine and Pharmacy, 400332 Cluj-Napoca, Romania., Domokos Gergely B; Department of Pneumology, 'Iuliu Hatieganu' University of Medicine and Pharmacy, 400332 Cluj-Napoca, Romania., Cabau G; Department of Medical Genetics, 'Iuliu Haţieganu' University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania., Tomoaia R; Heart Institute 'Nicolae Stancioiu', 400001 Cluj-Napoca, Romania.; Department of Cardiology, 'Iuliu Hatieganu' University of Medicine and Pharmacy, 400437 Cluj-Napoca, Romania., Chis AF; Department of Pneumology, 'Iuliu Hatieganu' University of Medicine and Pharmacy, 400332 Cluj-Napoca, Romania., Albu A; 2nd Internal Medicine Department, 'Iuliu Hatieganu' University of Medicine and Pharmacy, 400000 Cluj-Napoca, Romania., Stoia MA; Department of Internal Medicine, 'Iuliu Hatieganu' University of Medicine and Pharmacy, 400006 Cluj-Napoca, Romania., Vesa SC; Department of Pharmacology, Toxicology and Clinical Pharmacology, 'Iuliu Hatieganu' University of Medicine and Pharmacy, 400337 Cluj-Napoca, Romania., Blendea D; Department of Medicine, Faculty of Medicine, 'Iuliu Hatieganu' University of Medicine and Pharmacy, 400337 Cluj-Napoca, Romania., Todea DA; Department of Pneumology, 'Iuliu Hatieganu' University of Medicine and Pharmacy, 400332 Cluj-Napoca, Romania.
Jazyk:	angličtina
Zdroj:	Journal of personalized medicine [J Pers Med] 2021 Oct 02; Vol. 11 (10). Date of Electronic Publication: 2021 Oct 02.
DOI:	10.3390/jpm11101001
Abstrakt:	Background: Despite efforts at treatment, obstructive sleep apnea (OSA) remains a major health problem, especially with increasing evidence showing an association with cardiovascular morbidity and mortality. The treatment of choice for OSA patients is Continuous Positive Airway Pressure (CPAP), which has been proven in randomized controlled trials to be an effective therapy for this condition. The impact of CPAP on the cardiovascular pathology associated with OSA remains, however, unclear. Although the effect of CPAP has been previously studied in relation to cardiovascular outcome, follow-up of the treatment impact on cardiovascular risk factors at one year of therapy is lacking in a Romanian population. Thus, we aimed to evaluate the one-year effect of CPAP therapy on lipid profile, inflammatory state, blood pressure and cardiac function, assessed by echocardiography, on a cohort of Romanian OSA patients. Methods: We enrolled 163 participants and recorded their baseline demographic and clinical characteristics with a follow-up after 12 months. Inflammatory and cardiovascular risk factors were assessed at baseline and follow up. Results: Our results show that CPAP therapy leads to attenuation of cardiovascular risk factors including echocardiographic parameters, while having no effect on inflammatory markers. Conclusion: Treatment of OSA with CPAP proved to have beneficial effects on some of the cardiovascular risk factors while others remained unchanged, raising new questions for research into the treatment and management of OSA patients.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu