Obesity-An Update on the Basic Pathophysiology and Review of Recent Therapeutic Advances.

Autor: Gjermeni E; Department of Electrophysiology, Heart Center Leipzig at University of Leipzig, 04289 Leipzig, Germany.; Department of Cardiology, Median Centre for Rehabilitation Schmannewitz, 04774 Dahlen, Germany., Kirstein AS; Pediatric Research Center, University Hospital for Children and Adolescents, Leipzig University, 04103 Leipzig, Germany., Kolbig F; Pediatric Research Center, University Hospital for Children and Adolescents, Leipzig University, 04103 Leipzig, Germany., Kirchhof M; Department of Cardiology, Median Centre for Rehabilitation Schmannewitz, 04774 Dahlen, Germany., Bundalian L; Institute of Human Genetics, University Medical Center Leipzig, 04103 Leipzig, Germany., Katzmann JL; Klinik und Poliklinik für Kardiologie, University Clinic Leipzig, 04103 Leipzig, Germany., Laufs U; Klinik und Poliklinik für Kardiologie, University Clinic Leipzig, 04103 Leipzig, Germany., Blüher M; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München at the University of Leipzig and University Hospital Leipzig, 04103 Leipzig, Germany., Garten A; Pediatric Research Center, University Hospital for Children and Adolescents, Leipzig University, 04103 Leipzig, Germany., Le Duc D; Institute of Human Genetics, University Medical Center Leipzig, 04103 Leipzig, Germany.; Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum München at the University of Leipzig and University Hospital Leipzig, 04103 Leipzig, Germany.; Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, 04103 Leipzig, Germany.
Jazyk: angličtina
Zdroj: Biomolecules [Biomolecules] 2021 Sep 29; Vol. 11 (10). Date of Electronic Publication: 2021 Sep 29.
DOI: 10.3390/biom11101426
Abstrakt: Obesity represents a major public health problem with a prevalence increasing at an alarming rate worldwide. Continuous intensive efforts to elucidate the complex pathophysiology and improve clinical management have led to a better understanding of biomolecules like gut hormones, antagonists of orexigenic signals, stimulants of fat utilization, and/or inhibitors of fat absorption. In this article, we will review the pathophysiology and pharmacotherapy of obesity including intersection points to the new generation of antidiabetic drugs. We provide insight into the effectiveness of currently approved anti-obesity drugs and other therapeutic avenues that can be explored.
Databáze: MEDLINE
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