| Autor: |
Sandhu SS; Department of Nanoengineering, University of California, San Diego, La Jolla, California 92093, United States., Kotagiri YG; Department of Nanoengineering, University of California, San Diego, La Jolla, California 92093, United States., Fernando I PUAI; Bennett Aerospace, 1100 Crescent Green, No. 250, Cary, North Carolina 27518, United States., Kalaj M; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093, United States., Tostado N; Department of Nanoengineering, University of California, San Diego, La Jolla, California 92093, United States., Teymourian H; Department of Nanoengineering, University of California, San Diego, La Jolla, California 92093, United States., Alberts EM; Simetri, Inc., 7005 University Boulevard, Winter Park, Florida 32792, United States., Thornell TL; Geotechnical and Structures Laboratory, U.S. Army Engineer Research and Development Center, 3909 Halls Ferry Road, Vicksburg, Mississippi 39180, United States., Jenness GR; Environmental Laboratory, U.S. Army Engineer Research and Development Center, 3909 Halls Ferry Road, Vicksburg, Mississippi 39180, United States., Harvey SP; U.S. Army Combat Capabilities and Development Command-Chemical Biological Center (CCDC-CBC), Aberdeen Proving Ground, Maryland 21010, United States., Cohen SM; Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093, United States., Moores LC; Environmental Laboratory, U.S. Army Engineer Research and Development Center, 3909 Halls Ferry Road, Vicksburg, Mississippi 39180, United States., Wang J; Department of Nanoengineering, University of California, San Diego, La Jolla, California 92093, United States. |
| Abstrakt: |
Rapid and robust sensing of nerve agent (NA) threats is necessary for real-time field detection to facilitate timely countermeasures. Unlike conventional phosphotriesterases employed for biocatalytic NA detection, this work describes the use of a new, green, thermally stable, and biocompatible zirconium metal-organic framework (Zr-MOF) catalyst, MIP-202(Zr). The biomimetic Zr-MOF-based catalytic NA recognition layer was coupled with a solid-contact fluoride ion-selective electrode (F-ISE) transducer, for potentiometric detection of diisopropylfluorophosphate (DFP), a F-containing G-type NA simulant. Catalytic DFP degradation by MIP-202(Zr) was evaluated and compared to the established UiO-66-NH 2 catalyst. The efficient catalytic DFP degradation with MIP-202(Zr) at near-neutral pH was validated by 31 P NMR and FT-IR spectroscopy and potentiometric F-ISE and pH-ISE measurements. Activation of MIP-202(Zr) using Soxhlet extraction improved the DFP conversion rate and afforded a 2.64-fold improvement in total percent conversion over UiO-66-NH 2 . The exceptional thermal and storage stability of the MIP-202/F-ISE sensor paves the way toward remote/wearable field detection of G-type NAs in real-world environments. Overall, the green, sustainable, highly scalable, and biocompatible nature of MIP-202(Zr) suggests the unexploited scope of such MOF catalysts for on-body sensing applications toward rapid on-site detection and detoxification of NA threats. |
