Left Cardiac Remodelling Assessed by Echocardiography Is Associated with Rho-Kinase Activation in Long-Distance Runners.

Autor:	Contreras-Briceño F; Advanced Center for Chronic Diseases (ACCDiS), Division of Cardiovascular Diseases, Faculty of Medicine, Pontificia Universidad Católica de Chile, Av. Sergio Livingstone #1007, Santiago 8380492, Chile.; Laboratory of Exercise Physiology, Department of Health Science, Faculty of Medicine, Pontificia Universidad Católica de Chile, Av. Vicuña Mackenna #4860, Santiago 7820436, Chile.; Physiology Section, Department of Cell Biology, Physiology and Immunology, Faculty of Biology, Universitat de Barcelona, Av. Diagonal #643, 08028 Barcelona, Spain., Vega J; Advanced Center for Chronic Diseases (ACCDiS), Division of Cardiovascular Diseases, Faculty of Medicine, Pontificia Universidad Católica de Chile, Av. Sergio Livingstone #1007, Santiago 8380492, Chile., Mandiola J; Advanced Center for Chronic Diseases (ACCDiS), Division of Cardiovascular Diseases, Faculty of Medicine, Pontificia Universidad Católica de Chile, Av. Sergio Livingstone #1007, Santiago 8380492, Chile., Ocaranza MP; Advanced Center for Chronic Diseases (ACCDiS), Division of Cardiovascular Diseases, Faculty of Medicine, Pontificia Universidad Católica de Chile, Av. Sergio Livingstone #1007, Santiago 8380492, Chile.; Center of New Drugs for Hypertension (CENDHY), Universidad de Chile & Pontificia Universidad Católica de Chile, Av. Santos Dumont #964, Santiago 8380494, Chile., Herrera S; Advanced Center for Chronic Diseases (ACCDiS), Division of Cardiovascular Diseases, Faculty of Medicine, Pontificia Universidad Católica de Chile, Av. Sergio Livingstone #1007, Santiago 8380492, Chile., Salinas M; Advanced Center for Chronic Diseases (ACCDiS), Division of Cardiovascular Diseases, Faculty of Medicine, Pontificia Universidad Católica de Chile, Av. Sergio Livingstone #1007, Santiago 8380492, Chile., Fernández R; Advanced Center for Chronic Diseases (ACCDiS), Division of Cardiovascular Diseases, Faculty of Medicine, Pontificia Universidad Católica de Chile, Av. Sergio Livingstone #1007, Santiago 8380492, Chile., Jalil JE; Advanced Center for Chronic Diseases (ACCDiS), Division of Cardiovascular Diseases, Faculty of Medicine, Pontificia Universidad Católica de Chile, Av. Sergio Livingstone #1007, Santiago 8380492, Chile.; Center of New Drugs for Hypertension (CENDHY), Universidad de Chile & Pontificia Universidad Católica de Chile, Av. Santos Dumont #964, Santiago 8380494, Chile., Lavandero S; Advanced Center for Chronic Diseases (ACCDiS), Faculty of Chemical & Pharmaceutical Sciences & Faculty of Medicine, Universidad de Chile, Av. Sergio Livingstone #1007, Santiago 8380492, Chile.; Department of Internal Medicine, Cardiology Division, University of Texas Southwestern Medical Center, Av. Harry Hines Blvd #5323, Dallas, TX 75390-8573, USA., Chiong M; Advanced Center for Chronic Diseases (ACCDiS), Faculty of Chemical & Pharmaceutical Sciences & Faculty of Medicine, Universidad de Chile, Av. Sergio Livingstone #1007, Santiago 8380492, Chile., Godoy P; Advanced Center for Chronic Diseases (ACCDiS), Division of Cardiovascular Diseases, Faculty of Medicine, Pontificia Universidad Católica de Chile, Av. Sergio Livingstone #1007, Santiago 8380492, Chile., Castro PF; Advanced Center for Chronic Diseases (ACCDiS), Division of Cardiovascular Diseases, Faculty of Medicine, Pontificia Universidad Católica de Chile, Av. Sergio Livingstone #1007, Santiago 8380492, Chile., Sitges M; Thorax Institute, IDIBAPS, Hospital Clinic, Av. Carrer del Rosselló #149, 08036 Barcelona, Spain., Gabrielli L; Advanced Center for Chronic Diseases (ACCDiS), Division of Cardiovascular Diseases, Faculty of Medicine, Pontificia Universidad Católica de Chile, Av. Sergio Livingstone #1007, Santiago 8380492, Chile.; Laboratory of Exercise Physiology, Department of Health Science, Faculty of Medicine, Pontificia Universidad Católica de Chile, Av. Vicuña Mackenna #4860, Santiago 7820436, Chile.
Jazyk:	angličtina
Zdroj:	Journal of cardiovascular development and disease [J Cardiovasc Dev Dis] 2021 Sep 24; Vol. 8 (10). Date of Electronic Publication: 2021 Sep 24.
DOI:	10.3390/jcdd8100118
Abstrakt:	This single-blind and cross-sectional study evaluated the role of Rho-kinase (ROCK) as a biomarker of the cardiovascular remodelling process assessed by echocardiography in competitive long-distance runners (LDRs) during the training period before a marathon race. Thirty-six healthy male LDRs (37.0 ± 5.3 years; 174.0 ± 7.0 height; BMI: 23.8 ± 2.8; V˙ O 2 -peak: 56.5 ± 7.3 mL·kg -1 ·min -1 ) were separated into two groups according to previous training level: high-training (HT, n = 16) ≥ 100 km·week -1 and low-training (LT, n = 20) ≥ 70 and < 100 km·week -1 . Also, twenty-one healthy nonactive subjects were included as a control group (CTR). A transthoracic echocardiography was performed and ROCK activity levels in circulating leukocytes were measured at rest (48 h without exercising) the week before the race. The HT group showed a higher left ventricular mass index (LVMi) and left atrial volume index (LAVi) than other groups ( p < 0.05, for both); also, higher levels of ROCK activity were found in LDRs (HT = 6.17 ± 1.41 vs. CTR = 1.64 ± 0.66 ( p < 0.01); vs. LT = 2.74 ± 0.84; ( p < 0.05)). In LDRs a direct correlation between ROCK activity levels and LVMi (r = 0.83; p < 0.001), and LAVi (r = 0.70; p < 0.001) were found. In conclusion, in male competitive long-distance runners, the load of exercise implicated in marathon training is associated with ROCK activity levels and the left cardiac remodelling process assessed by echocardiography.
Databáze:	MEDLINE
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