Cholangiocarcinoma and liver transplantation: What we know so far?

Autor:	Safarpour AR; Department of Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz 7134814336, Iran., Askari H; Department of Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz 7134814336, Iran., Ejtehadi F; The Princess Alexandra Hospital HNS Trust, Harlow, Essex CM20 1QX, United Kingdom., Azarnezhad A; Liver and Digestive Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj 6617913446, Iran., Raeis-Abdollahi E; Department of Basic Medical Sciences, Qom Medical Branch, Islamic Azad University, Qom, Iran., Tajbakhsh A; Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz 7134814336, Iran., Abazari MF; Research Center for Clinical Virology, Tehran University of Medical Sciences, Tehran 1417653761, Iran., Tarkesh F; Department of Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz 7134814336, Iran., Shamsaeefar A; Shiraz Organ Transplant Center, Shiraz University of Medical Sciences, Shiraz 7193711351, Iran., Niknam R; Department of Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz 7134814336, Iran., Sivandzadeh GR; Department of Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz 7134814336, Iran., Lankarani KB; Health Policy Research Centre, Shiraz University of Medical Sciences, Shiraz 7134814336, Iran., Ejtehadi F; Department of Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz 7134814336, Iran. edjtehadif@sums.ac.ir.
Jazyk:	angličtina
Zdroj:	World journal of gastrointestinal pathophysiology [World J Gastrointest Pathophysiol] 2021 Sep 22; Vol. 12 (5), pp. 84-105.
DOI:	10.4291/wjgp.v12.i5.84
Abstrakt:	Cholangiocarcinoma (CCA) is a type of cancer with increasing prevalence around the world that originates from cholangiocytes, the epithelial cells of the bile duct. The tumor begins insidiously and is distinguished by high grade neoplasm, poor outcome, and high risk for recurrence. Liver transplantation has become broadly accepted as a treatment option for CCA. Liver transplantation is expected to play a crucial role as palliative and curative therapy for unresectable hilar CCA and intrahepatic CCA. The purpose of this study was to determine which cases with CCA should be subjected to liver transplantation instead of resection, although reported post-transplant recurrence rate averages approximately 20%. This review also aims to highlight the molecular current frontiers of CCA and directions of liver transplantation for CCA. Competing Interests: Conflict-of-interest statement: The authors declare no conflict of interest. (©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu