Impact of the day of the week on the discontinuation of broad-spectrum antibiotic prescriptions; a multi-centered observational study.

Autor: Honda H; Department of General Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine, 2-5-1 Shikata-cho, Kitaku, Okayama, 700-8558, Japan., Hagiya H; Department of General Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine, 2-5-1 Shikata-cho, Kitaku, Okayama, 700-8558, Japan. hagiya@okayama-u.ac.jp., Higashionna T; Department of Pharmacy, Okayama University Hospital, 2-5-1 Shikata-cho, Kitaku, Okayama, 700-8558, Japan., Haruki Y; Department of Pharmacy, Tsuyama Chuo Hospital, 1756 Kawasaki, Tsuyama, Okayama, 708-0841, Japan., Haruki M; Department of Pharmacy, Tsuyama Chuo Hospital, 1756 Kawasaki, Tsuyama, Okayama, 708-0841, Japan., Kajita S; Department of Pharmacy, Okayama City Hospital, 3-20-1 Kitanagaseomotemachi, Kitaku, Okayama, 700-8557, Japan., Mukuda K; Department of Internal Medicine, Yonago Medical Center, 4-17-1 Kuzumo, Yonago, Tottori, 863-0006, Japan., Yokoyama Y; Department of Pharmacy, Marugame Medical Center, 219 Tsunomori-cho, Marugame, Kagawa, 763-8507, Japan., Nakano Y; Department of General Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine, 2-5-1 Shikata-cho, Kitaku, Okayama, 700-8558, Japan., Ogawa H; Department of General Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine, 2-5-1 Shikata-cho, Kitaku, Okayama, 700-8558, Japan., Morimoto Y; Department of Pharmacy, Kasaoka City Hospital, 5628-1 Kasaoka, Kasaoka, Okayama, 714-0081, Japan., Hanayama Y; Department of General Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine, 2-5-1 Shikata-cho, Kitaku, Okayama, 700-8558, Japan., Kanda S; Department of Nursing, Okayama Kyokuto Hospital, 567-1 Kurata, Nakaku, Okayama, 703-8265, Japan., Kataoka H; Department of General Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine, 2-5-1 Shikata-cho, Kitaku, Okayama, 700-8558, Japan., Muguruma H; Department of Pharymacy, Okayama Memorial Hospital, 7-22 Seikihonmachi, Kitaku, Okayama, 700-0862, Japan., Otsuka F; Department of General Medicine, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine, 2-5-1 Shikata-cho, Kitaku, Okayama, 700-8558, Japan.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2021 Oct 21; Vol. 11 (1), pp. 20784. Date of Electronic Publication: 2021 Oct 21.
DOI: 10.1038/s41598-021-00206-9
Abstrakt: To encourage and guide antimicrobial stewardship team (AST) activity and promote appropriate antibiotic use, we studied the impact of day of the week on the initiation and discontinuation of antibiotic administration. This was a multicenter observational study conducted at 8 Japanese hospitals from April 1 to September 30, 2019, targeting patients who underwent treatment with broad-spectrum antibiotics, such as anti-methicillin-resistant Staphylococcus aureus agents and anti-pseudomonal agents. We compared the weekly numbers of initiations and discontinuations of antibiotic prescription on each day of the week or on the days after a holiday. There was no statistical difference in the number of antibiotic initiations on both weekdays and the day after a holiday. However, antibiotic discontinuation was significantly higher from Tuesday onward than Monday and from the second day than the first day after a holiday. Similar trends were observed regardless of the categories of antibiotics, hospital and admission ward, and AST activity. This study suggests that broad-spectrum antibiotics tend to be continued during weekends and holidays and are most likely to be discontinued on Tuesday or the second day after a holiday. This was probably due to behavioral factors beyond medical indications, requiring further antimicrobial stewardship efforts in the future.
(© 2021. The Author(s).)
Databáze: MEDLINE
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