Glia maturation factor-γ is involved in S1P-induced marginal zone B-cell chemotaxis and optimal IgM production to type II T-independent antigen.

Autor:	Li Y; Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, China., Tang Y; Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, China., Liu J; Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, China., Meng X; Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, China., Wang Y; Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, China., Min Q; Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, China., Hong R; School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China., Tsubata T; Department of Immunology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan., Hase K; Division of Biochemistry, Faculty of Pharmacy, Keio University, Tokyo, Japan., Wang JY; Department of Immunology, School of Basic Medical Sciences, Fudan University, Shanghai, China.; Department of Immunology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan.; Department of Clinical Immunology, Children's Hospital of Fudan University, Shanghai, China.; Department of Microbiology and Immunology, College of Basic Medical Sciences, Zhengzhou University, Zhengzhou, China.
Jazyk:	angličtina
Zdroj:	International immunology [Int Immunol] 2022 Jan 01; Vol. 34 (1), pp. 35-43.
DOI:	10.1093/intimm/dxab097
Abstrakt:	Marginal zone B cells (MZBs) represent a unique B-cell sub-population that rapidly differentiate into IgM-secreting plasma cells in response to T-independent (T-I) antigen. Sphingosine 1-phosphate (S1P) promotes MZB localization to the marginal zone. However, intracellular molecules involved in MZB localization and migration remain largely unknown. Here, we show that MZBs lacking the glia maturation factor-γ (GMFG) are impaired in chemotaxis toward S1P under both in vitro and in vivo conditions, suggesting that GMFG is an effector downstream of S1P receptors. GMFG undergoes serine phosphorylation upon S1P stimulation and is required for S1P-induced desensitization of S1P receptor 1 (S1PR1). Compared with wild-type mice, Gmfg-/- mice produce elevated levels of 4-hydroxy-3-nitrophenyl-acetyl (NP)-specific IgM against a T-I type II antigen, NP-Ficoll, accompanied by dysregulated MZB localization. These results identify GMFG as a regulator of S1P-induced MZB chemotaxis and reveal a role for MZB localization in the marginal zone for optimal IgM production against a T-I antigen. (© The Japanese Society for Immunology. 2021. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
Databáze:	MEDLINE
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