Corifollitropin alpha, clomiphene citrate and dydrogesterone without daily gonadotrophin: a new option of a friendly protocol for high-responder oocyte donors.

Autor:	Melo AS; CEFERP - Fertility Center of Ribeirão Preto. Ribeirão Preto, São Paulo, Brazil., Paula CTV; CEFERP - Fertility Center of Ribeirão Preto. Ribeirão Preto, São Paulo, Brazil., Santos TLD; CEFERP - Fertility Center of Ribeirão Preto. Ribeirão Preto, São Paulo, Brazil., Faria VAC; CEFERP - Fertility Center of Ribeirão Preto. Ribeirão Preto, São Paulo, Brazil., Rufato MAF; CEFERP - Fertility Center of Ribeirão Preto. Ribeirão Preto, São Paulo, Brazil., Barboza RP; CEFERP - Fertility Center of Ribeirão Preto. Ribeirão Preto, São Paulo, Brazil., Barreto J; CEFERP - Fertility Center of Ribeirão Preto. Ribeirão Preto, São Paulo, Brazil.
Jazyk:	angličtina
Zdroj:	JBRA assisted reproduction [JBRA Assist Reprod] 2022 Apr 17; Vol. 26 (2), pp. 315-320. Date of Electronic Publication: 2022 Apr 17.
DOI:	10.5935/1518-0557.20210082
Abstrakt:	Objective: To compare the number of oocytes obtained in the follicular puncture of high- responder oocyte donors, submitted to ovarian stimulation for in vitro fertilization (IVF) in two different protocols: Friendly and Conventional. Methods: There were one hundred-and-eight infertile egg-donor women, aged between 21 and 35 years, undergoing IVF in this retrospective cohort study. The women were divided into two groups: 1) Friendly protocol: controlled ovarian stimulation (COS) with corifollitropin alpha, clomiphene citrate and dydrogesterone without daily rFSH (n=52) and 2) In the Conventional protocol, we had COS with menotropin daily and ganirelix (n=66). We assessed age, body mass index, time and cause of infertility, antral follicle count (AFC) by three-dimensional ultrasound, number of visits to the clinic, COS duration, number of follicles ≥14mm on the trigger day, early ovulation frequency, number of mature oocytes, number of cryopreserved embryos, clinical pregnancy rate, frequency of OHSS. Results: The ovulatory factor was higher in women in the Conventional protocol (p=0.03), and the tubal factor (p=0.02) was higher in the Friendly protocol group. The number of visits to the clinic was lower among women in the Friendly protocol (p=0.04). The number of mature eggs, the clinical pregnancy rate and the frequency of OHSS were similar between the groups. The number of frozen embryos was higher in the Friendly group (p=0.02). The regression model demonstrated that the ovulatory factor, the tubal factor and the number of visits to the clinic were not predictors of the number of mature oocytes. Only AFC was an independent predictor of the number of meiosis II oocytes (p<0.01). Conclusions: The Friendly protocol seems to be as safe and effective as the Conventional protocol for infertile high-responder oocyte donors, resulting in a similar number of mature oocytes and OHSS incidence.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu