iRhom1 rescues cognitive dysfunction in multiple sclerosis via preventing myelin injury.
| Autor: | Sun H; School of Basic Medical Sciences, Anhui Medical University, Hefei, China., Yang H; School of Basic Medical Sciences, Anhui Medical University, Hefei, China., Wu Y; School of Basic Medical Sciences, Anhui Medical University, Hefei, China., Bian H; School of Basic Medical Sciences, Anhui Medical University, Hefei, China., Wang M; School of Basic Medical Sciences, Anhui Medical University, Hefei, China., Huang Y; School of Pharmacy, Anhui Medical University, Hefei, China., Jin J; School of Basic Medical Sciences, Anhui Medical University, Hefei, China. |
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| Jazyk: | angličtina |
| Zdroj: | Genes, brain, and behavior [Genes Brain Behav] 2021 Nov; Vol. 20 (8), pp. e12771. Date of Electronic Publication: 2021 Oct 21. |
| DOI: | 10.1111/gbb.12771 |
| Abstrakt: | Multiple sclerosis (MS) is characterized by myelin sheath injury. A disintegrin and metalloprotease-17 (ADAM17), a disintegrin and metalloproteinase, is essential in regulating oligodendrocyte (OL) regeneration and remyelination under demyelinating conditions. iRhom1, a highly conserved inactive protease that belongs to the rhomboid family, is one of key regulators for ADAM17 maturation. However, it is unknown whether iRhom1 also plays a role in central neuron system myelination under demyelinating conditions like MS. In this study, we investigated the function of iRhom1/ADAM17 in cognitive capability in MS by establishing the mice with iRhom1 overexpression in the hippocampus. (© 2021 The Authors. Genes, Brain and Behavior published by International Behavioural and Neural Genetics Society and John Wiley & Sons Ltd.) |
| Databáze: | MEDLINE |
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