Theta oscillations in rat infralimbic cortex are associated with the inhibition of cocaine seeking during extinction.

Autor: Müller Ewald VA; Department of Psychiatry, University of Iowa, Iowa City, Iowa, USA.; Interdisciplinary Neuroscience Program, University of Iowa, Iowa City, Iowa, USA., Kim J; Interdisciplinary Neuroscience Program, University of Iowa, Iowa City, Iowa, USA.; Department of Psychological and Brain Sciences, University of Iowa, Iowa City, Iowa, USA., Farley SJ; Interdisciplinary Neuroscience Program, University of Iowa, Iowa City, Iowa, USA.; Department of Psychological and Brain Sciences, University of Iowa, Iowa City, Iowa, USA., Freeman JH; Interdisciplinary Neuroscience Program, University of Iowa, Iowa City, Iowa, USA.; Department of Psychological and Brain Sciences, University of Iowa, Iowa City, Iowa, USA.; Iowa Neuroscience Institute, University of Iowa, Iowa City, Iowa, USA., LaLumiere RT; Interdisciplinary Neuroscience Program, University of Iowa, Iowa City, Iowa, USA.; Department of Psychological and Brain Sciences, University of Iowa, Iowa City, Iowa, USA.; Iowa Neuroscience Institute, University of Iowa, Iowa City, Iowa, USA.
Jazyk: angličtina
Zdroj: Addiction biology [Addict Biol] 2022 Jan; Vol. 27 (1), pp. e13106. Date of Electronic Publication: 2021 Oct 20.
DOI: 10.1111/adb.13106
Abstrakt: Infralimbic cortical (IL) manipulations indicate that this region mediates extinction learning and suppresses cocaine seeking following cocaine self-administration. However, little work has recorded IL activity during the inhibition of cocaine seeking due to the difficulty of determining precisely when cocaine-seeking behaviour is inhibited within a cocaine-seeking session. The present study used in vivo electrophysiology to examine IL activity across extinction as well as during cocaine self-administration and reinstatement. Sprague-Dawley rats underwent 6-h access cocaine self-administration in which the response lever was available during discrete signalled trials, a procedure which allowed for the comparison between epochs of cocaine seeking versus the inhibition thereof. Subsequently, rats underwent extinction and cocaine-primed reinstatement using the same procedure. Results indicate that theta rhythms (4-10 Hz) dominated IL local-field potential (LFP) activity during all experimental stages. During extinction, theta power fluctuated significantly surrounding the lever press and was lower when rats engaged in cocaine seeking versus when they withheld from doing so. These patterns of oscillatory activity differed from self-administration and reinstatement stages. Single-unit analyses indicate heterogeneity of IL unit responses, supporting the idea that multiple neuronal subpopulations exist within the IL and promote the expression of different and even opposing cocaine-seeking behaviours. Together, these results are consistent with the idea that aggregate synaptic and single-unit activity in the IL represent the engagement of the IL in action monitoring to promote adaptive behaviour in accordance with task contingencies and reveal critical insights into the relationship between IL activity and the inhibition of cocaine seeking.
(© 2021 The Authors. Addiction Biology published by John Wiley & Sons Ltd on behalf of Society for the Study of Addiction.)
Databáze: MEDLINE
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