Prognostic Role of Monocytic Myeloid-Derived Suppressor Cells in Advanced Non-Small-Cell Lung Cancer: Relation to Different Hematologic Indices.

Autor: Zahran AM; Clinical Pathology Department, South Egypt Cancer Institute, Assiut University, Egypt., Hetta HF; Department of Medical Microbiology and Immunology, Faculty of Medicine, Assiut University, Assiut 71526, Egypt., Zahran ZAM; Department of Clinical Pathology, Faculty of Medicine, Assiut University, Assiut, Egypt., Rashad A; Department of Chest Diseases and Tuberculosis, Qena Faculty of Medicine, South Valley University, Egypt., Rayan A; Clinical Oncology Department, Faculty of Medicine, Assiut University, Egypt., Mohamed DO; Radiation Oncology Department, South Egypt Cancer Institute, Assiut University, Egypt., Elhameed ZAA; Department of Clinical Pathology, Faculty of Medicine, Assiut University, Assiut, Egypt., Khallaf SM; Medical Oncology Department, South Egypt Cancer Institute, Assiut University, Egypt., Batiha GE; Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Damanhour University, Damanhour City, Egypt., Waheed Y; Foundation University Medical College, Foundation University Islamabad, Islamabad 44000, Pakistan., Muhammad K; Department of Biology, College of Science, United Arab Emirates University, Al Ain 15551, UAE., Nafady-Hego H; Department of Medical Microbiology and Immunology, Faculty of Medicine, Assiut University, Assiut 71526, Egypt.
Jazyk: angličtina
Zdroj: Journal of immunology research [J Immunol Res] 2021 Oct 11; Vol. 2021, pp. 3241150. Date of Electronic Publication: 2021 Oct 11 (Print Publication: 2021).
DOI: 10.1155/2021/3241150
Abstrakt: Methods: We recruited 40 cases of advanced NSCLC, stages III and IV, aged > 18-<70 years old, and eligible to receive chemotherapy with or without radiotherapy, along with 20 healthy controls of comparable age and sex; after diagnosis and staging of patients, blood samples were collected for flow cytometric detection of Mo-MDSCs.
Results: Significant accumulation of Mo-MDSCs in patients compared to their controls ( p < 0.0001). Furthermore, these cells accumulated significantly in stage IV compared to stage III ( p = 0.006) and correlated negatively with overall survival ( r = -0.471, p = 0.002), lymphocyte to monocyte ratio ( r = -0.446, p = 0.004), and mean platelet volume to platelet count ratio (MPV/PC) ( r = -0.464, p = 0.003), patients with Mo-MDSCs < 13% had significantly better survival than those with Mo-MDSCs ≥ 13% ( p = 0.041).
Conclusion: Mo-MDSCs represent one of the key mechanisms in the immunosuppressive tumor microenvironment (TME) to play major roles not only in the carcinogenesis of lung cancer but also in disease progression and prognosis and, in addition, predict the efficacy of immune checkpoint inhibitors; our results provided some support to target Mo-MDSCs and needed to be augmented by further studies.
Competing Interests: The authors declare that they have no conflicts of interest.
(Copyright © 2021 Asmaa M. Zahran et al.)
Databáze: MEDLINE
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