An Unusual Presentation of Community-Acquired Methicillin-Resistant Staphylococcus aureus Infection in a Child Treated With Linezolid.
| Autor: | Alshengeti A; Department of Pediatrics, Taibah University, Al-Madinah, SAU., Alamri R; Department of Pediatrics, Madinah Maternity and Children Hospital, Al-Madinah, SAU., Tharwat R; Department of Pediatrics, Madinah Maternity and Children Hospital, Al-Madinah, SAU., Alahmadi H; Department of Pediatrics, Madinah Maternity and Children Hospital, Al-Madinah, SAU., Alawfi A; Department of Pediatrics, Taibah University, Al-Madinah, SAU., Arkoubi M; Department of Radiology, Madinah Maternity and Children Hospital, Al-Madinah, SAU., Alrashidi Y; Department of Orthopedics, Taibah University, Al-Madinah, SAU. |
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| Jazyk: | angličtina |
| Zdroj: | Cureus [Cureus] 2021 Oct 16; Vol. 13 (10), pp. e18830. Date of Electronic Publication: 2021 Oct 16 (Print Publication: 2021). |
| DOI: | 10.7759/cureus.18830 |
| Abstrakt: | Methicillin-resistant Staphylococcus aureus (MRSA) infection is a major public health concern. MRSA isolates are classified into community-acquired MRSA (CA-MRSA) and healthcare-associated MRSA based on their epidemiology, antibiotic susceptibility patterns, and molecular characteristics. CA-MRSA typically causes skin and soft tissue infections. However, the incidence of invasive infections has increased in recent years. This paper describes the case of a 12-year-old girl with an unusual presentation of CA-MRSA. The patient presented with right thigh pyomyositis complicated by deep vein thrombosis, septic pulmonary embolism, and necrotizing pneumonia. The MRSA isolate was susceptible to vancomycin but resistant to the other anti-MRSA antibiotics. The patient was successfully treated with linezolid after clinical deterioration with vancomycin. A literature review comparing vancomycin and linezolid in invasive MRSA infections among children indicated that linezolid has better lung and tissue penetration than vancomycin, and an early switch is warranted in the case of deterioration after vancomycin administration and the lack of other alternatives. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2021, Alshengeti et al.) |
| Databáze: | MEDLINE |
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