Methylsulfonylmethane Increases the Alveolar Bone Density of Mandibles in Aging Female Mice.

Autor:	Aljohani H; Department of Oncology and Diagnostic Sciences, School of Dentistry, University of Maryland, Baltimore, Baltimore, MD, United States.; Department of Oral Medicine and Diagnostics Sciences, School of Dentistry, King Saud University, Riyadh, Saudi Arabia., Senbanjo LT; Department of Oncology and Diagnostic Sciences, School of Dentistry, University of Maryland, Baltimore, Baltimore, MD, United States., Al Qranei M; Department of Oncology and Diagnostic Sciences, School of Dentistry, University of Maryland, Baltimore, Baltimore, MD, United States.; Department of Preventive Dental Sciences, School of Dentistry, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia., Stains JP; Department of Orthopedics, University of Maryland School of Medicine, Baltimore, MD, United States., Chellaiah MA; Department of Oncology and Diagnostic Sciences, School of Dentistry, University of Maryland, Baltimore, Baltimore, MD, United States.
Jazyk:	angličtina
Zdroj:	Frontiers in physiology [Front Physiol] 2021 Oct 04; Vol. 12, pp. 708905. Date of Electronic Publication: 2021 Oct 04 (Print Publication: 2021).
DOI:	10.3389/fphys.2021.708905
Abstrakt:	Methylsulfonylmethane (MSM) is a naturally occurring anti-inflammatory compound that effectively treats multiple degenerative diseases such as osteoarthritis and acute pancreatitis. Our previous studies have demonstrated the ability of MSM to differentiate stem cells from human exfoliated deciduous (SHED) teeth into osteoblast-like cells. This study examined the systemic effect of MSM in 36-week-old aging C57BL/6 female mice in vivo by injecting MSM for 13 weeks. Serum analyses showed an increase in expression levels of bone formation markers [osteocalcin (OCN) and procollagen type 1 intact N-terminal propeptide (P1NP)] and a reduction in bone resorption markers [tartrate-resistant acid phosphatase (TRAP) and C-terminal telopeptide of type I collag (CTX-I)] in MSM-injected animals. Micro-computed tomographic images demonstrated an increase in trabecular bone density in mandibles. The trabecular bone density tended to be higher in the femur, although the increase was not significantly different between the MSM- and phosphate-buffered saline (PBS)-injected mice. In mandibles, an increase in bone density with a corresponding decrease in the marrow cavity was observed in the MSM-injected mice. Furthermore, immunohistochemical analyses of the mandibles for the osteoblast-specific marker - OCN, and the mesenchymal stem cell-specific marker - CD105 showed a significant increase and decrease in OCN and CD105 positive cells, respectively. Areas of bone loss were observed in the inter-radicular region of mandibles in control mice. However, this loss was considerably decreased due to stimulation of bone formation in response to MSM injection. In conclusion, our study has demonstrated the ability of MSM to induce osteoblast formation and function in vivo , resulting in increased bone formation in the mandible. Hence, the application of MSM and stem cells of interest may be the right combination in alveolar bone regeneration under periodontal or other related diseases that demonstrate bone loss. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2021 Aljohani, Senbanjo, Al Qranei, Stains and Chellaiah.)
Databáze:	MEDLINE
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