Linking Physical Activity to Breast Cancer via Sex Hormones, Part 1: The Effect of Physical Activity on Sex Steroid Hormones.

Autor:	Swain CTV; Cancer Epidemiology Division, Cancer Council Victoria, Victoria, Australia., Drummond AE; Cancer Epidemiology Division, Cancer Council Victoria, Victoria, Australia., Boing L; Laboratory of Research in Leisure and Physical Activity, Santa Catarina State University, Florianópolis, Brazil., Milne RL; Cancer Epidemiology Division, Cancer Council Victoria, Victoria, Australia.; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.; Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Melbourne, Victoria, Australia., English DR; Cancer Epidemiology Division, Cancer Council Victoria, Victoria, Australia.; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia., Brown KA; Department of Medicine, Weill Cornell Medicine, New York, New York., van Roekel EH; Department of Epidemiology, GROW School for Oncology and Developmental Biology, Maastricht University, Maastricht, the Netherlands., Dixon-Suen SC; Cancer Epidemiology Division, Cancer Council Victoria, Victoria, Australia.; Institute for Physical Activity and Nutrition, Deakin University, Geelong, Victoria, Australia., Lynch MJ; Nambour Heights Family Medical, Nambour, Queensland, Australia., Moore MM; Medical Oncology, St Vincent's Hospital, Melbourne, Victoria, Australia., Gaunt TR; Bristol Medical School, University of Bristol, Bristol, United Kingdom., Martin RM; Bristol Medical School, University of Bristol, Bristol, United Kingdom.; NIHR Biomedical Research Centre at University Hospitals Bristol and Weston NHS Foundation Trust and the University of Bristol, Bristol, United Kingdom., Lewis SJ; Bristol Medical School, University of Bristol, Bristol, United Kingdom., Lynch BM; Cancer Epidemiology Division, Cancer Council Victoria, Victoria, Australia. brigid.lynch@cancervic.org.au.; Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.
Jazyk:	angličtina
Zdroj:	Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology [Cancer Epidemiol Biomarkers Prev] 2022 Jan; Vol. 31 (1), pp. 16-27. Date of Electronic Publication: 2021 Oct 20.
DOI:	10.1158/1055-9965.EPI-21-0437
Abstrakt:	The effect of physical activity on breast cancer risk may be partly mediated by sex steroid hormones. This review synthesized and appraised the evidence for an effect of physical activity on sex steroid hormones. Systematic searches were performed using MEDLINE (Ovid), EMBASE (Ovid), and SPORTDiscus to identify experimental studies and prospective cohort studies that examined physical activity and estrogens, progestins, and/or androgens, as well as sex hormone binding globulin (SHBG) and glucocorticoids in pre- and postmenopausal women. Meta-analyses were performed to generate effect estimates. Risk of bias was assessed, and the GRADE system was used to appraise quality of the evidence. Twenty-eight randomized controlled trials (RCT), 81 nonrandomized interventions, and six observational studies were included. Estrogens, progesterone, and androgens mostly decreased, and SHBG increased, in response to physical activity. Effect sizes were small, and evidence quality was graded moderate or high for each outcome. Reductions in select sex steroid hormones following exercise supports the biological plausibility of the first part of the physical activity-sex hormone-breast cancer pathway. The confirmed effect of physical activity on decreasing circulating sex steroid hormones supports its causal role in preventing breast cancer. See related reviews by Lynch et al., p. 11 and Drummond et al., p. 28 . (©2021 The Authors; Published by the American Association for Cancer Research.)
Databáze:	MEDLINE
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