Hepatitis-Associated Aplastic Anemia: Etiology, Clinical Characteristics and Outcome.

Autor:	Tüfekçi Ö; Department of Pediatric Hematology, Dokuz Eylül University Faculty of Medicine., Özdemir HH; Department of Pediatric Hematology, Ege University Faculty of Medicine., Malbora B; Department of Pediatric Hematology/Oncology, Ankara City Hospital, The University of Health Sciences, Ankara., Özbek NY; Department of Pediatric Hematology/Oncology, Ankara City Hospital, The University of Health Sciences, Ankara., Yarali N; Department of Pediatric Hematology/Oncology, Ankara City Hospital, The University of Health Sciences, Ankara., Erdem A; Department of Pediatric Hematology/Oncology, Ankara City Hospital, The University of Health Sciences, Ankara., Evim M; Department of Pediatric Hematology, Uludağ University Faculty of Medicine, Bursa., Baytan B; Department of Pediatric Hematology, Uludağ University Faculty of Medicine, Bursa., Güneş AM; Department of Pediatric Hematology, Uludağ University Faculty of Medicine, Bursa., Karapinar T; Department of Pediatric Hematology/Oncology, İstinye University Faculty of Medicine, İstanbul, Turkey., Oymak Y; Department of Pediatric Hematology/Oncology, İstinye University Faculty of Medicine, İstanbul, Turkey., Töret E; Department of Pediatric Hematology, Osmangazi University Faculty of Medicine, Eskişehir., Bör Ö; Department of Pediatric Hematology, Osmangazi University Faculty of Medicine, Eskişehir., Yilmaz Ş; Department of Pediatric Hematology, Dokuz Eylül University Faculty of Medicine., Ören H; Department of Pediatric Hematology, Dokuz Eylül University Faculty of Medicine., Özdemir GN; Department of Pediatric Hematology/Oncology, İstinye University Faculty of Medicine, İstanbul, Turkey., Karapinar DY; Department of Pediatric Hematology, Ege University Faculty of Medicine.
Jazyk:	angličtina
Zdroj:	Journal of pediatric hematology/oncology [J Pediatr Hematol Oncol] 2022 Jan 01; Vol. 44 (1), pp. e223-e226.
DOI:	10.1097/MPH.0000000000002268
Abstrakt:	Hepatitis-associated aplastic anemia (HAA) is a form of acquired aplastic anemia (AA) in which bone marrow failure develops after an acute attack of hepatitis. Bone marrow failure leading to AA is generally severe in cases of HAA and fatal if left untreated. This retrospective multicenter study investigated clinical and laboratory characteristics, possible causes, treatment, and outcome of HAA in children. Twenty patients from 8 centers were included in the study. Aspartate aminotransferase and alanine aminotransferase were <3 to 5×upper limit of normal (ULN) in 2 patients, <5 to 10×ULN in 2 patients, and >10×ULN in 16 patients. Acute liver failure developed in 5 (29%) patients. Pancytopenia was simultaneously present in 6 of 20 (30%) patients. Eleven of the 20 patients (55%) were alive, in remission and transfusion free. Those who were alive either had undergone hematopoietic stem cell transplantation and/or immunosuppressive treatment, except 1 patient who had received no treatment. Patients with the diagnosis of acute hepatitis should be evaluated and followed up carefully for presence of cytopenia, so that definitive treatment of AA can be initiated in a timely and appropriate manner when needed. Competing Interests: The authors declare no conflict of interest. (Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.)
Databáze:	MEDLINE
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