Patterns of Carbon-Bound Exogenous Compounds in Patients with Lung Cancer and Association with Disease Pathophysiology.

Autor:	Kunzke T; Research Unit Analytical Pathology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Prade VM; Research Unit Analytical Pathology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Buck A; Research Unit Analytical Pathology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Sun N; Research Unit Analytical Pathology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Feuchtinger A; Research Unit Analytical Pathology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Matzka M; Research Unit Analytical Pathology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Fernandez IE; Department of Internal Medicine V, Comprehensive Pneumology Center Munich (CPC-M), Member of the German Center for Lung Research (DZL), Ludwig-Maximilians-Universität München, Munich, Germany.; Institute of Lung Biology and Disease, Comprehensive Pneumology Center, Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Munich, Germany., Wuyts W; Department of Respiratory Diseases, University Hospitals Leuven, Leuven, Belgium., Ackermann M; Institute of Functional and Clinical Anatomy, University Medical Center Mainz, Johannes Gutenberg-University Mainz, Mainz, Germany.; Institute of Pathology and Molecular Pathology, Helios University Hospital Wuppertal, University of Witten/Herdecke, Wuppertal, Germany., Jonigk D; Institute of Pathology, Hannover Medical School, Hannover, Germany. Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH).; German Center for Lung Research (DZL), Hannover Medical School, Hannover, Germany., Aichler M; Research Unit Analytical Pathology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany., Schmid RA; Department of General Thoracic Surgery, Inselspital University Hospital Bern, Bern, Switzerland., Eickelberg O; Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania., Berezowska S; Institute of Pathology, University of Bern, Bern, Switzerland. axel.walch@helmholtz-muenchen.de sabina.berezowska@chuv.ch.; Department of Laboratory Medicine and Pathology, Institute of Pathology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland., Walch A; Research Unit Analytical Pathology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany. axel.walch@helmholtz-muenchen.de sabina.berezowska@chuv.ch.
Jazyk:	angličtina
Zdroj:	Cancer research [Cancer Res] 2021 Dec 01; Vol. 81 (23), pp. 5862-5875. Date of Electronic Publication: 2021 Oct 19.
DOI:	10.1158/0008-5472.CAN-21-1175
Abstrakt:	Asymptomatic anthracosis is the accumulation of black carbon particles in adult human lungs. It is a common occurrence, but the pathophysiologic significance of anthracosis is debatable. Using in situ high mass resolution matrix-assisted laser desorption/ionization (MALDI) fourier-transform ion cyclotron resonance (FT-ICR) mass spectrometry imaging analysis, we discovered noxious carbon-bound exogenous compounds, such as polycyclic aromatic hydrocarbons (PAH), tobacco-specific nitrosamines, or aromatic amines, in a series of 330 patients with lung cancer in highly variable and unique patterns. The characteristic nature of carbon-bound exogenous compounds had a strong association with patient outcome, tumor progression, the tumor immune microenvironment, programmed death-ligand 1 (PD-L1) expression, and DNA damage. Spatial correlation network analyses revealed substantial differences in the metabolome of tumor cells compared with tumor stroma depending on carbon-bound exogenous compounds. Overall, the bioactive pool of exogenous compounds is associated with several changes in lung cancer pathophysiology and correlates with patient outcome. Given the high prevalence of anthracosis in the lungs of adult humans, future work should investigate the role of carbon-bound exogenous compounds in lung carcinogenesis and lung cancer therapy. SIGNIFICANCE: This study identifies a bioactive pool of carbon-bound exogenous compounds in patient tissues associated with several tumor biological features, contributing to an improved understanding of drivers of lung cancer pathophysiology. (©2021 American Association for Cancer Research.)
Databáze:	MEDLINE
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