Dietary supplementation with casein glycomacropeptide, leucine and tryptophan reduces plasma amino acid levels in men.

Autor:	Larsen ER; Mental Health Department Odense, University Clinic, Mental Health Service, Region of Southern Denmark, Odense, Denmark.; Department of Regional Health Research, University of Southern Denmark, Esbjerg, Denmark., Juel A; Department of Regional Health Research, University of Southern Denmark, Esbjerg, Denmark., Jensen E; Arla Foods Ingredients Group P/S, Viby J, Denmark., Hollyer TR; Arla Foods Ingredients Group P/S, Viby J, Denmark., Wegener G; Department of Clinical Medicine, Translational Neuropsychiatry Unit, Aarhus C., Denmark.
Jazyk:	angličtina
Zdroj:	Acta neuropsychiatrica [Acta Neuropsychiatr] 2022 Apr; Vol. 34 (2), pp. 69-76. Date of Electronic Publication: 2021 Oct 20.
DOI:	10.1017/neu.2021.34
Abstrakt:	Background: The treatment of mania in bipolar disorders needs to be more efficient, as the manic condition creates severe problems for the patient when it comes to work, finances, relationships and health. This proof-of-concept study examines to what extent casein glycomacropeptide (CGMP) may reduce the precursors of dopamine, phenylalanine and tyrosine, in plasma, and therefore be a potential new intervention to treat acute manic episodes. Method: The study was designed as a double-blind randomised dose-response study of CGMP (with added leucine and tryptophan) in 15 healthy men, receiving 3 different doses of CGMP with an interval of at least 14 days. Results: Administration of CGMP produced a dose-dependent depletion of plasma aromatic amino acids. The total area under the curve of plasma ratios of phenylalanine-tyrosine compared to the level of leucine-isoleucine-valine--tryptophan was CGMP (20 g): 3.648 [SE:0.3281]; CGMP (40 g): 2.368 [SE:0.1858]; and CGMP (60 g)1.887 [SE:0.2591]. A comparison of the groups showed a dose-dependent statistical difference, with a one-way ANOVA summary (Dunnett) F = 11.87, p = 0.0003, CGMP 20 g versus CGMP 40 g, p = 0.0042, CGMP 20 g versus CGMP 60 g, p = 0.0002. No significant side effects were observed. Conclusions: This study demonstrate CGMP is a well-tolerated and effective mixture, and that 60 g of CGMP produced the highest depletion of plasma aromatic amino acids (phenylalanine and tyrosine). The effect seems to be highest after 3-4 h. We therefore conclude that this dose should be the one considered for future studies involving CGMP in humans.
Databáze:	MEDLINE
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