Symptoms and oxylipins in plasma before and after exposure to rooms in which individuals have both experienced and not experienced building-related symptoms - an exploratory study.

Autor: Claeson AS; Department of Psychology, Umeå University, Umeå, Sweden., Sommar J; Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden., Liljelind I; Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.
Jazyk: angličtina
Zdroj: International journal of environmental health research [Int J Environ Health Res] 2022 Dec; Vol. 32 (12), pp. 2756-2766. Date of Electronic Publication: 2021 Oct 19.
DOI: 10.1080/09603123.2021.1988908
Abstrakt: The aim of this study was to investigate if there are differences in symptom ratings and plasma concentrations of oxylipins as a measure of acute inflammation between individuals with building-related symptoms (BRS) and referents during exposure to rooms where people experienced BRS and rooms where they did not experience BRS. Medically examined individuals with BRS and healthy, age and sex matched referents working in the same building were exposed for 60 min. Ratings of symptoms and collection of blood to measure oxylipins in plasma were performed before and after each exposure. Individuals with BRS reported more symptoms (mostly mucosal) than the referents in the problem rooms and there was a tendency towards a difference between the groups in concentration of metabolites from the cyclooxygenase pathway (COX). The mean reported intensity of symptoms among all participants was also found to be positively correlated with both COX and lipoxygenase (LOX-15) oxylipins in problem rooms.
Databáze: MEDLINE
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