High SARS-CoV-2 seroprevalence in persons experiencing homelessness and shelter workers from a day-shelter in São Paulo, Brazil.

Autor: do Couto AC; Graduate College of Cellular and Molecular Biology, Federal University of Paraná (UFPR), Curitiba, Paraná, Brazil., Kmetiuk LB; Graduate College of Cellular and Molecular Biology, Federal University of Paraná (UFPR), Curitiba, Paraná, Brazil., Delai RR; Graduate College of Cellular and Molecular Biology, Federal University of Paraná (UFPR), Curitiba, Paraná, Brazil., Brandão APD; Department of Preventive Medicine, University of São Paulo Medical School (FMUSP), São Paulo, São Paulo, Brazil., Monteiro CO; Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil., da Silva LHA; Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil., Soares C; Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil., Banari AC; Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil., Bach RVW; Department of Medicine, State University of Ponta Grossa, Ponta Grossa, Paraná, Brazil., Pettan-Brewer C; Department of Comparative Medicine, University of Washington, Seattle, Washington, United States of America., Dos Santos AP; Department of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, Indiana, United States of America., Guimarães AMS; Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil., Oliveira DBL; Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil., Durigon EL; Department of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil., Biondo AW; Graduate College of Cellular and Molecular Biology, Federal University of Paraná (UFPR), Curitiba, Paraná, Brazil.
Jazyk: angličtina
Zdroj: PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2021 Oct 19; Vol. 15 (10), pp. e0009754. Date of Electronic Publication: 2021 Oct 19 (Print Publication: 2021).
DOI: 10.1371/journal.pntd.0009754
Abstrakt: Brazil presents one of the highest COVID-19 death tolls in the world. The initial SARS-CoV-2 epicenter was São Paulo city. As of 2019, the homeless population of São Paulo city was estimated at 24,344 individuals, the largest national homeless population. The present study aimed to concomitantly assess the molecular and serological prevalence and associated risk factors of SARS-CoV-2 infection in a homeless population and related shelter workers from a day-shelter. Serum samples, nasopharyngeal and oropharyngeal swabs of persons who are homeless and shelter workers collected from August 25th to 27th, 2020 were tested for the presence of anti-SARS-CoV-2 IgM and IgG antibodies by ELISA and SARS-CoV-2 RNA by RT-qPCR, respectively. All swab samples tested negative by RT-qPCR. Seropositivity of IgM and IgG was 5/203 (2.5%) and 111/203 (54.7%) in persons who are homeless, and 5/87 (5.7%) and 41/87 (47.1%) in shelter workers, respectively, with no statistical differences between groups. The high seroprevalence found herein indicates early environmental and urban spreading of SARS-CoV-2, associated with sociodemographic and economic vulnerability.
Competing Interests: The authors have declared that no competing interests exist.
Databáze: MEDLINE
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