Endothelial dysfunction biomarkers in sickle cell disease: is there a role for ADMA and PAI-1?

Gln polymorphism in Korean patients with coronary artery disease. J Korean Med Sci 15:146–152. https://doi.org/10.3346/jkms.2000.15.2.146. (PMID: 10.3346/jkms.2000.15.2.146108036893054611)
Ataga KI, Brittain JE, Desai P, May R, Jones S, Delaney J, Strayhorn D, Hinderliter A, Key NS (2012) Association of coagulation activation with clinical complications in sickle cell disease. PLoS ONE. https://doi.org/10.1371/journal.pone.0029786. (PMID: 10.1371/journal.pone.0029786222537813256184)
Laurentino MR, Filho SLAP, Parente LLC, Júnior GBS, Daher EDF, Lemes RPG (2019) Non-invasive urinary biomarkers of renal function in sickle cell disease: an overview. Ann Hematol 98:2653–2660. https://doi.org/10.1007/s00277-019-03813-9. (PMID: 10.1007/s00277-019-03813-931641850)
Belisário AR, Silva AA, Silva CV, Souza LM, Wakabayashi EA, Araújo SA, Silva ACSE (2019) Sickle cell disease nephropathy: an update on risk factors and potential biomarkers in pediatric patients. Biomark Med 13:967–987. https://doi.org/10.2217/bmm-2019-0105. (PMID: 10.2217/bmm-2019-010531390894)
Heimlich JB, Chipoka G, Elsherif L, David E, Ellis G, Kamthunzi P, Krysiak R, Mafunga P, Zhou Q, Cai J, Gopal S, Key NS, Ataga KI (2018) Nephrin as a biomarker of sickle cell glomerulopathy in Malawi. Pediatr Blood Cancer 65:1–7. https://doi.org/10.1002/pbc.26993. (PMID: 10.1002/pbc.26993) -->
Grant Information: 001 CAPES; 404353/2016-9 CNPq; 311185/2019-3 CNPq; 00764-16 FAPEMIG
Contributed Indexing: Keywords: ADMA; Endothelial dysfunction; PAI-1; Sickle cell disease
Substance Nomenclature: 0 (Biomarkers)
0 (Plasminogen Activator Inhibitor 1)
0 (SERPINE1 protein, human)
63CV1GEK3Y (N,N-dimethylarginine)
94ZLA3W45F (Arginine)
Entry Date(s): Date Created: 20211019 Date Completed: 20220120 Latest Revision: 20220120
Update Code: 20221213
DOI: 10.1007/s00277-021-04695-6
PMID: 34665295
Autor: Martins SR; Department of Clinical and Toxicological Analysis, Faculty of Pharmacy, Federal University of Minas Gerais, Avenida Antonio Carlos, 6627, Pampulha, Belo Horizonte, Minas Gerais, 31270901, Brazil., Toledo SLO; Federal University of São João del-Rei (UFSJ), Campus Centro-Oeste Dona Lindu, Sebastião Gonçalves Coelho Street, 400, Building: D, Room: 308.1, ChanadourDivinópolis, MG, 35501-296, Brazil., da Silva AJ; Department of Clinical and Toxicological Analysis, Faculty of Pharmacy, Federal University of Minas Gerais, Avenida Antonio Carlos, 6627, Pampulha, Belo Horizonte, Minas Gerais, 31270901, Brazil., Mendes FS; Department of Clinical and Toxicological Analysis, Faculty of Pharmacy, Federal University of Minas Gerais, Avenida Antonio Carlos, 6627, Pampulha, Belo Horizonte, Minas Gerais, 31270901, Brazil., de Oliveira MM; Federal University of São João del-Rei (UFSJ), Campus Centro-Oeste Dona Lindu, Sebastião Gonçalves Coelho Street, 400, Building: D, Room: 308.1, ChanadourDivinópolis, MG, 35501-296, Brazil.; Fundação Centro de Hematologia E Hemoterapia Do Estado de Minas Gerais, (Hemominas), Divinópolis, MG, Brazil., Ferreira LGR; Federal University of São João del-Rei (UFSJ), Campus Centro-Oeste Dona Lindu, Sebastião Gonçalves Coelho Street, 400, Building: D, Room: 308.1, ChanadourDivinópolis, MG, 35501-296, Brazil., Dusse LMS; Department of Clinical and Toxicological Analysis, Faculty of Pharmacy, Federal University of Minas Gerais, Avenida Antonio Carlos, 6627, Pampulha, Belo Horizonte, Minas Gerais, 31270901, Brazil., Carvalho MDG; Department of Clinical and Toxicological Analysis, Faculty of Pharmacy, Federal University of Minas Gerais, Avenida Antonio Carlos, 6627, Pampulha, Belo Horizonte, Minas Gerais, 31270901, Brazil.; Federal University of São João del-Rei (UFSJ), Campus Centro-Oeste Dona Lindu, Sebastião Gonçalves Coelho Street, 400, Building: D, Room: 308.1, ChanadourDivinópolis, MG, 35501-296, Brazil., Rios DRA; Federal University of São João del-Rei (UFSJ), Campus Centro-Oeste Dona Lindu, Sebastião Gonçalves Coelho Street, 400, Building: D, Room: 308.1, ChanadourDivinópolis, MG, 35501-296, Brazil., Alpoim PN; Department of Clinical and Toxicological Analysis, Faculty of Pharmacy, Federal University of Minas Gerais, Avenida Antonio Carlos, 6627, Pampulha, Belo Horizonte, Minas Gerais, 31270901, Brazil. patnessralla@yahoo.com.br., Pinheiro MB; Federal University of São João del-Rei (UFSJ), Campus Centro-Oeste Dona Lindu, Sebastião Gonçalves Coelho Street, 400, Building: D, Room: 308.1, ChanadourDivinópolis, MG, 35501-296, Brazil. melinapinheiro@ufsj.edu.br.
Jazyk: angličtina
Zdroj: Annals of hematology [Ann Hematol] 2022 Feb; Vol. 101 (2), pp. 273-280. Date of Electronic Publication: 2021 Oct 19.
DOI: 10.1007/s00277-021-04695-6
Abstrakt: Within the spectrum of sickle cell disease (SCD) are sickle cell anemia (SCA), presence of hemoglobin SS (HbSS), hemoglobin SC disease (HbSC), and sickle cell β-thalassemia (Sβ-thal). Asymmetric dimethylarginine (ADMA) competitively inhibits the binding of arginine to NOS, reducing NO production. In patients with HbSS, increased levels of ADMA have been reported, as well as changes in many hemostatic biomarkers, including the plasminogen activator inhibitor type 1 (PAI-1). We hypothesized that high levels of ADMA and PAI-1 may be associated with more severe SCD. Thus, ADMA and PAI-1 levels were determined in 78 individuals including 38 adult patients with SCD and 40 control subjects. Higher levels of ADMA were shown in HbSS and Sβ-thal patients compared to controls. Concerning PAI-1, all patients showed high levels of PAI-1 compared to controls. As a role of NO in the pathogenesis of SCD has already been established, we concluded that high levels of ADMA should compromise, at least in part, NO synthesis, resulting in endothelial dysfunction. Elevated plasma levels of PAI-1 in all patients may indicate not only endothelial dysfunction but also a hypofibrinolytic state favoring thrombotic complications. Finally, high levels of ADMA and PAI-1 may be associated with more severe SCD.
(© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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