Oral and gastric microbiome in relation to gastric intestinal metaplasia.

Autor: Wu F; Department of Population Health, New York University School of Medicine, New York, New York, USA., Yang L; Department of Medicine, New York University School of Medicine, New York, New York, USA., Hao Y; Department of Biology, New York University, New York, New York, USA., Zhou B; Department of Population Health, New York University School of Medicine, New York, New York, USA., Hu J; Department of Population Health, New York University School of Medicine, New York, New York, USA., Yang Y; Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Bedi S; Department of Population Health, New York University School of Medicine, New York, New York, USA., Sanichar NG; Department of Population Health, New York University School of Medicine, New York, New York, USA., Cheng C; Department of Population Health, New York University School of Medicine, New York, New York, USA., Perez-Perez G; Department of Medicine, New York University School of Medicine, New York, New York, USA., Tseng W; Department of Population Health, New York University School of Medicine, New York, New York, USA., Tseng W; Amherst College, Amherst, Massachusetts, USA., Tseng M; Department of Medicine, New York University School of Medicine, New York, New York, USA., Francois F; Department of Medicine, New York University School of Medicine, New York, New York, USA., Khan AR; Department of Medicine, New York University School of Medicine, New York, New York, USA., Li Y; Department of Microbiology and Immunology, Cornell University Master of Public Health Program, Ithaca, New York, USA., Blaser MJ; Center for Advanced Biotechnology and Medicine, Rutgers University, Piscataway, New Jersey, USA., Shu XO; Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Long J; Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Li H; Department of Population Health, New York University School of Medicine, New York, New York, USA., Pei Z; Department of Medicine, New York University School of Medicine, New York, New York, USA.; Department of Pathology, New York University School of Medicine, New York, New York, USA.; Department of Pathology and Lab Service, Veterans Affairs New York Harbor Healthcare System, New York, New York, USA., Chen Y; Department of Population Health, New York University School of Medicine, New York, New York, USA.; Department of Environmental Medicine, New York University School of Medicine, New York, New York, USA.
Jazyk: angličtina
Zdroj: International journal of cancer [Int J Cancer] 2022 Mar 15; Vol. 150 (6), pp. 928-940. Date of Electronic Publication: 2021 Nov 05.
DOI: 10.1002/ijc.33848
Abstrakt: Evidence suggests that Helicobacter pylori plays a role in gastric cancer (GC) initiation. However, epidemiologic studies on the specific role of other bacteria in the development of GC are lacking. We conducted a case-control study of 89 cases with gastric intestinal metaplasia (IM) and 89 matched controls who underwent upper gastrointestinal endoscopy at three sites affiliated with NYU Langone Health. We performed shotgun metagenomic sequencing using oral wash samples from 89 case-control pairs and antral mucosal brushing samples from 55 case-control pairs. We examined the associations of relative abundances of bacterial taxa and functional pathways with IM using conditional logistic regression with and without elastic-net penalty. Compared with controls, oral species Peptostreptococcus stomatis, Johnsonella ignava, Neisseria elongata and Neisseria flavescens were enriched in cases (odds ratios [ORs] = 1.29-1.50, P = .004-.01) while Lactobacillus gasseri, Streptococcus mutans, S parasanguinis and S sanguinis were under-represented (ORs = 0.66-0.76, P = .006-.042) in cases. Species J ignava and Filifactor alocis in the gastric microbiota were enriched (ORs = 3.27 and 1.43, P = .005 and .035, respectively), while S mutans, S parasanguinis and S sanguinis were under-represented (ORs = 0.61-0.75, P = .024-.046), in cases compared with controls. The lipopolysaccharide and ubiquinol biosynthesis pathways were more abundant in IM, while the sugar degradation pathways were under-represented in IM. The findings suggest potential roles of certain oral and gastric microbiota, which are correlated with regulation of pathways associated with inflammation, in the development of gastric precancerous lesions.
(© 2021 UICC.)
Databáze: MEDLINE
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