Acute right ventricular failure associated with pulmonary hypertension in pediatrics: understanding the hemodynamic profiles.

Autor: Evers PD; Division of Pediatric Cardiology, Oregon Health and Sciences University, Portland, OR, USA. eversp@ohsu.edu., Scottoline B; Division of Neonatology, Oregon Health and Sciences University, Portland, OR, USA., Armsby LB; Division of Pediatric Cardiology, Oregon Health and Sciences University, Portland, OR, USA.
Jazyk: angličtina
Zdroj: Journal of perinatology : official journal of the California Perinatal Association [J Perinatol] 2022 Jan; Vol. 42 (1), pp. 139-142. Date of Electronic Publication: 2021 Oct 18.
DOI: 10.1038/s41372-021-01231-2
Abstrakt: Pulmonary hypertension (PHTN) is a common pathology in pediatrics, arising from a diverse array of etiologies and manifesting in equally diverse patient populations. The inpatient management of these infants and children may be complicated by dynamic and at times severe increases in pulmonary vascular resistance (PVR) and right ventricular (RV) afterload. Yet absent are cognitively accessible heuristics in the field whereby providers can reconcile the various clinical manifestations they observe with an understanding of the cardiac physiology at play, and therefore, appropriate physiology-driven interventions. Described herein is a framework for understanding the pathophysiology of four clinical phenotypes which are driven by two echocardiographic patient characteristics: the presence or absence of an atrial communication and the capacity of the right ventricle to maintain ventricular-vascular coupling. Application of this paradigm may facilitate accurate interpretation of observed clinical data, and alignment of treatment strategies with the underlying pathophysiology.
(© 2021. The Author(s), under exclusive licence to Springer Nature America, Inc.)
Databáze: MEDLINE
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