Polysaccharide isolated from Passiflora edulis: Characterization and antitumor properties.

Autor: Silva DC; Departamento de Bioquímica, Universidade Federal do Ceará, Ceará, Brazil., Freitas ALP; Departamento de Bioquímica, Universidade Federal do Ceará, Ceará, Brazil., Barros FCN; Departamento de Bioquímica, Universidade Federal do Ceará, Ceará, Brazil., Lins KOAL; Departamento de Fisiologia e Farmacologia, Universidade Federal do Ceará, Ceará, Brazil., Alves APNN; Departamento de Clínica Odontológica, Universidade Federal do Ceará, Fortaleza, Ceará, Brazil., Alencar NMN; Departamento de Fisiologia e Farmacologia, Universidade Federal do Ceará, Ceará, Brazil., de Figueiredo IST; Departamento de Fisiologia e Farmacologia, Universidade Federal do Ceará, Ceará, Brazil., Pessoa C; Departamento de Fisiologia e Farmacologia, Universidade Federal do Ceará, Ceará, Brazil., de Moraes MO; Departamento de Fisiologia e Farmacologia, Universidade Federal do Ceará, Ceará, Brazil., Costa-Lotufo LV; Departamento de Fisiologia e Farmacologia, Universidade Federal do Ceará, Ceará, Brazil., Feitosa JPA; Departamento de Química Orgânica e Inorgânica, Universidade Federal do Ceará, CP 6.021, CEP 60455-760, Fortaleza, Ceará, Brazil., Maciel JS; Departamento de Química Orgânica e Inorgânica, Universidade Federal do Ceará, CP 6.021, CEP 60455-760, Fortaleza, Ceará, Brazil., de Paula RCM; Departamento de Química Orgânica e Inorgânica, Universidade Federal do Ceará, CP 6.021, CEP 60455-760, Fortaleza, Ceará, Brazil. Electronic address: rpaula@dqoi.ufc.br.
Jazyk: angličtina
Zdroj: Carbohydrate polymers [Carbohydr Polym] 2012 Jan 04; Vol. 87 (1), pp. 139-145. Date of Electronic Publication: 2011 Jul 27.
DOI: 10.1016/j.carbpol.2011.07.029
Abstrakt: A hot water-extracted polysaccharide fraction (PFCM) of Passiflora edulis was characterized by microanalysis, infrared spectroscopy, NMR and high performance size-exclusion chromatography. The major component in PFCM is (1→4) linked galacturonic acid (esterified and unesterified). Neutral sugars such as arabinose, glucose, rhamnose, mannose, and fucose were also present. Traces of xylose and ribose were detected. The PFCM sample had a similar molar mass to that of pectin extracted from P. edulis under acidic conditions. Sarcoma 180 tumors treated with PFCM showed a growth inhibition ratio ranging from 40.59% to 48.73% depending on the dosage and type of PFCM administration (oral or intraperitoneal). Toxicological analysis shows that PFCM increases the cell types involved in primary defense mechanisms and no significant changes in the biochemical parameters and organs (e.g., kidney and liver) were observed. However, the use of PFCM treatment increased the spleen weight when compared with the use of 5-fluorouracil.
(Copyright © 2011 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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