Design and Optimization of Stimuli-responsive Emulsion-filled Gel for Topical Delivery of Copaiba Oil-resin.

Autor:	Campanholi KDSS; Department of Chemistry, State University of Maringa, Maringa, Brazil. Electronic address: Katieli_souza@hotmail.com., da Silva JB; Department of Pharmacy, State University of Maringa, Maringa, Brazil., Batistela VR; Department of Technology, State University of Maringa, Umuarama, Brazil., Gonçalves RS; Department of Chemistry, State University of Maringa, Maringa, Brazil., Said Dos Santos R; Department of Pharmacy, State University of Maringa, Maringa, Brazil., Balbinot RB; Department of Basic Health Sciences, State University of Maringa, Maringa, Brazil., Lazarin-Bidóia D; Department of Basic Health Sciences, State University of Maringa, Maringa, Brazil., Bruschi ML; Department of Pharmacy, State University of Maringa, Maringa, Brazil., Nakamura TU; Department of Basic Health Sciences, State University of Maringa, Maringa, Brazil., Nakamura CV; Department of Basic Health Sciences, State University of Maringa, Maringa, Brazil., Caetano W; Department of Chemistry, State University of Maringa, Maringa, Brazil.
Jazyk:	angličtina
Zdroj:	Journal of pharmaceutical sciences [J Pharm Sci] 2022 Feb; Vol. 111 (2), pp. 287-292. Date of Electronic Publication: 2021 Oct 15.
DOI:	10.1016/j.xphs.2021.10.003
Abstrakt:	This study presents a phytotherapeutic emulsion-filled gel design composed of Pluronic® F127, Carbopol® C934P, and high level of copaiba oil-resin (PHY-ECO). Mathematical modeling and response surface methodology (RSM) were employed to access the optimal ratio between the oil and the polymer gel-matrix constituents. The chemometric approach showed robust mechanical and thermoresponsive properties for emulsion gel. The model predicts viscosity parameters at 35.0°C (skin temperature) from PHY-ECOs. Optimized PHY-ECOs were described by 18-20% (w/w) F127, 0.25% (w/w) C934P, and 15% (w/w) copaiba oil-resin, and showed interfacial layers properties that led to high physicochemical stability. Besides, it had thermal stimuli-responsive that led large viscosity range before and after skin administration, observed by oscillatory rheology. These behaviors give the optimized smart PHY-ECO high design potential to be used as a pharmaceutical platform for CO delivery, focusing on the anti-inflammatory therapy and skin wound care. Competing Interests: Declaration of Competing Interest We declare no conflicts of interest. (Copyright © 2021 American Pharmacists Association. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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