Handgrip strength as a simple measure for screening prediabetes and type 2 diabetes mellitus risk among adults in Malawi: A cross-sectional study.

Autor: Manda CM; Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan., Nakanga WP; Malawi Epidemiology and Intervention Research Unit, Lilongwe and Karonga, Malawi., Mkandawire J; Malawi Epidemiology and Intervention Research Unit, Lilongwe and Karonga, Malawi., Muula AS; School of Public Health and Family Medicine, College of Medicine, University of Malawi, Blantyre, Malawi.; The Africa Center of Excellence in Public Health and Herbal Medicine, University of Malawi, Blantyre, Malawi., Nyirenda MJ; London School of Hygiene and Tropical Medicine, London, UK., Crampin AC; Malawi Epidemiology and Intervention Research Unit, Lilongwe and Karonga, Malawi.; London School of Hygiene and Tropical Medicine, London, UK., Wagatsuma Y; Department of Clinical Trial and Clinical Epidemiology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.
Jazyk: angličtina
Zdroj: Tropical medicine & international health : TM & IH [Trop Med Int Health] 2021 Dec; Vol. 26 (12), pp. 1709-1717. Date of Electronic Publication: 2021 Nov 01.
DOI: 10.1111/tmi.13694
Abstrakt: Objective: Handgrip strength, a simple measure of muscle strength, has been reported as a predictor of both prediabetes and type 2 diabetes mellitus (T2DM) and has been suggested for screening prediabetes and T2DM risk. This study examined the relationship of handgrip strength with prediabetes and T2DM among rural- and urban-dwelling adults in Malawi.
Methods: This was a cross-sectional study nested in a follow-up study of prediabetic and prehypertensive individuals identified during an extensive noncommunicable disease survey in Malawi. A total of 261 participants (women: 64%) were recruited. Univariate and multivariate binary logistic regression analyses were performed to examine the association of prediabetes and T2DM with relative handgrip strength.
Results: The mean (SD) age of the participants was 49.7 (13.6) years, and 54.0% were between the ages of 40 and 59 years. The mean (SD) absolute handgrip strength and relative handgrip strength were 28.8 (7.3) kg and 1.16 (0.40) kg/BMI, respectively, and the mean relative handgrip strength differed significantly (p < 0.001) by T2DM status. In unadjusted model, the odds ratio (OR) of prediabetes and T2DM per unit increase in relative handgrip strength was 0.12 [95% CI; 0.04-0.33]. The result remained significant after adjusting for age (continuous), sex, place of study, hypertension, dyslipidaemia and level of education (aOR [95% CI]; 0.19 [0.03-0.95]).
Conclusions: The findings suggest that handgrip strength could be a relatively inexpensive, noninvasive measure for contributing to risk scores to identify high-risk individuals for screening diabetes in SSA.
(© 2021 John Wiley & Sons Ltd.)
Databáze: MEDLINE
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