Side effects of omeprazole: a system biology study.

Autor: Hamzeloo-Moghadam M; Traditional Medicine and Materia Medica Research Center and Department of Traditional Pharmacy, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Rezaei Tavirani M; Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Jahani-Sherafat S; Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Rezaei Tavirani S; Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Esmaeili S; Traditional Medicine and Materia Medica Research Center and Department of Traditional Pharmacy, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Ansari M; Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Ahmadzadeh A; Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Jazyk: angličtina
Zdroj: Gastroenterology and hepatology from bed to bench [Gastroenterol Hepatol Bed Bench] 2021 Fall; Vol. 14 (4), pp. 334-341.
Abstrakt: Aim: To assess the effects of omeprazole on the human cardiovascular system is the main aim of this study.
Background: Omeprazole as a proton pump inhibitor is widely consumed to inhibit gastric acid secretion.
Methods: Gene expression profiles of "human coronary artery endothelial cells" in the absence and presence of omeprazole were downloaded from the Gene Expression Omnibus (GEO) database. The differentially expressed genes (DEGs) interacted as an interactome, and the hub nodes are determined. The DEGs were enriched via gene ontology (GO) analysis. The critical hubs were identified based on the GO findings.
Results: Among 103 queried DEGs, 61 individuals were included in the main connected component. CTNNB1, HNRNPA1, SRSF4, TRA2A, SFPQ, and RBM5 genes were identified as critical hub genes. Six clusters of biological terms were introduced as deregulated elements in the presence of omeprazole.
Conclusion: In conclusion, long-term consumption of omeprazole may be accompanied with undesirable effects, however more evidence is required.
Competing Interests: The authors declare that they have no conflict of interest.
(©2021 RIGLD, Research Institute for Gastroenterology and Liver Diseases.)
Databáze: MEDLINE
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