Neuropsychiatric Symptoms in Behavioral Variant Frontotemporal Dementia and Alzheimer's Disease: A 12-Month Follow-Up Study.

Autor:	Da Silva TBL; Department of Neurology, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.; Gerontology, School of Arts, Sciences, and Humanities, University of São Paulo, São Paulo, Brazil., Ordonez TN; Gerontology, School of Arts, Sciences, and Humanities, University of São Paulo, São Paulo, Brazil.; Graduate Program in Applied Statistics, University Center of United Metropolitan Colleges, São Paulo, Brazil., Bregola AG; School of Health Sciences, Faculty of Medicine and Health Sciences, University of East Anglia, Norwich, United Kingdom., Bahia VS; Department of Neurology, Faculty of Medicine, University of São Paulo, São Paulo, Brazil., Cecchini MA; Department of Neurology, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.; Human Cognitive Neuroscience, Psychology, University of Edinburgh, Edinburgh, United Kingdom., Guimarães HC; Neurology Division, University Hospital, Federal University of Minas Gerais, Belo Horizonte, Brazil., Gambogi LB; Neurology Division, University Hospital, Federal University of Minas Gerais, Belo Horizonte, Brazil., Caramelli P; Neurology Division, University Hospital, Federal University of Minas Gerais, Belo Horizonte, Brazil., Balthazar MLF; Neuroimaging Laboratory, School of Medical Sciences, University of Campinas (UNICAMP), Campinas, Brazil., Damasceno BP; Neurology Department, University of Campinas, Campinas, Brazil., Brucki SMD; Department of Neurology, Faculty of Medicine, University of São Paulo, São Paulo, Brazil., de Souza LC; Neurology Division, University Hospital, Federal University of Minas Gerais, Belo Horizonte, Brazil., Nitrini R; Department of Neurology, Faculty of Medicine, University of São Paulo, São Paulo, Brazil., Yassuda MS; Department of Neurology, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.; Gerontology, School of Arts, Sciences, and Humanities, University of São Paulo, São Paulo, Brazil.
Jazyk:	angličtina
Zdroj:	Frontiers in neurology [Front Neurol] 2021 Sep 30; Vol. 12, pp. 728108. Date of Electronic Publication: 2021 Sep 30 (Print Publication: 2021).
DOI:	10.3389/fneur.2021.728108
Abstrakt:	Introduction: Neuropsychiatric symptoms in patients with frontotemporal dementia (FTD) are highly prevalent and may complicate clinical managements. Objective: To test whether the Neuropsychiatry Inventory (NPI) could detect change in neuropsychiatric symptoms and caregiver's distress in patients diagnosed with behavioral variant frontotemporal dementia (bvFTD) and Alzheimer's disease (AD) from baseline to a 12-month follow-up and to investigate possible predictors of change in NPI scores. Methods: The sample consisted of 31 patients diagnosed with bvFTD and 28 patients with AD and their caregivers. The Mini-Mental State Examination (MMSE), Addenbrooke's Cognitive Examination Revised (ACE-R), the INECO Frontal Screening (IFS), the Frontal Assessment Battery (FAB), the Executive Interview (EXIT-25) and the NPI were applied. Descriptive statistics, Mann-Whitney U test, Wilcoxon test, Chi square (χ 2 ) test and Linear Regression Analysis were used. Results: NPI total and caregiver distress scores were statistically higher among bvFTD patients at both assessment points. MMSE, ACE-R scores significantly declined and NPI Total and Distress scores significantly increased in both groups. In the bvFTD group, age was the only independent predictor variable for the NPI total score at follow up. In the AD group, ACE-R and EXIT-25, conjunctively, were associated with the NPI total score at follow up. Conclusions: In 12 months, cognition declined and neuropsychiatric symptoms increased in bvFTD and AD groups. In the AD group only, cognitive impairment was a significant predictor of change in neuropsychiatric symptoms. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2021 Da Silva, Ordonez, Bregola, Bahia, Cecchini, Guimarães, Gambogi, Caramelli, Balthazar, Damasceno, Brucki, de Souza, Nitrini and Yassuda.)
Databáze:	MEDLINE
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