Clinico-histopathological Profile of Primary Paediatric Intra-abdominal Tumours: a Multi-hospital-Based Study.

Autor: Joseph N; Post Graduate Diploma in Family Medicine, Department of Community Medicine, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka India., Rai S; Department of Pathology, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka India., Singhal K; Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka India., Saha S; Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka India., Chakraborty D; Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka India., Badoni G; Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka India., Revanth T; Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka India., Lobo FD; Department of Pathology, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka India.
Jazyk: angličtina
Zdroj: Indian journal of surgical oncology [Indian J Surg Oncol] 2021 Sep; Vol. 12 (3), pp. 517-523. Date of Electronic Publication: 2021 Jun 08.
DOI: 10.1007/s13193-021-01365-x
Abstrakt: Paediatric cancers are gradually on the rise in India. Its proportion among children aged < 15 years constitutes close to 5% of the total cancer affected population. A high proportion of this constitutes intra-abdominal tumours. This study was done to study the demographic profile, clinical features and management of intra-abdominal tumours among children. Data of all histopathologically confirmed patients aged < 15 years with various primary intra-abdominal tumours diagnosed from 2009 to 2019 were included in this study. The median age of the patients (n = 50) was 3 years (IQR 1.4, 6). The median age at diagnosis of cancer (n = 23) was 2.5 years (IQR 1, 4). Tumours were more common among males (70%). The most common tumour in this study was Wilm's tumour (17 (34%)). Forty-eight (96%) patients had malignant tumours. Fever was present among the majority (27 (54%)) of the patients. The most common anti-cancer drug used for management was Vincristine, used among 23 patients. Remission was more among infants with Wilm's tumour ( P  = 0.0221) and among patients with Hodgkin's lymphoma (HL) ( P  = 0.0444). Default with treatment was more among patients with stage 4 malignancy ( P  = 0.0186). Recovery following treatment was more among patients with germ cell tumour ( P  = 0.0082). Reasons for default with treatment in the late stages of malignancies need to be identified in future research studies.
Supplementary Information: The online version contains supplementary material available at 10.1007/s13193-021-01365-x.
Competing Interests: Competing InterestsThe authors declare no competing interests.
(© Indian Association of Surgical Oncology 2021.)
Databáze: MEDLINE
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