SARS-CoV-2 infection in early first-trimester miscarriages: a prospective observational study.

Autor: González Rodríguez L; Department of Gynecology and Obstetrics, Hospital Alvaro Cunqueiro, Vigo Pontevedra, Spain., Oreja Cuesta AB; Department of Gynecology and Obstetrics, Hospital del Tajo, Madrid, Spain. Electronic address: oscarmartinezgine@gmail.com., Pardo Pumar MI; Department of Gynecology and Obstetrics, Complejo Hospitalario Universitario de Pontevedra Pontevedra, Spain., Ferriols-Pérez E; Department of Gynecology and Obstetrics, Hospital Universitari Parc de Salut Mar Barcelona, Spain., Pedró Carulla R; Department of Gynecology and Obstetrics, Hospital Sant Joan de Reus Tarragona, Spain., Bernardo Vega R; Department of Gynecology and Obstetrics, Hospital Universitario Río Hortega, Valladolid, Spain., Vaquerizo Ruiz Ó; Department of Gynecology and Obstetrics, Hospital Universitario de Cabueñes Asturias, Spain., de la Cruz Conty ML; Fundación de Investigación Biomédica, Puerta de Hierro University Hospital of Majadahonda, Madrid, Spain., Couceiro Naveira E; Department of Gynecology and Obstetrics, Hospital Alvaro Cunqueiro, Vigo Pontevedra, Spain., Marín Ortiz E; Department of Gynecology and Obstetrics, Hospital Alvaro Cunqueiro, Vigo Pontevedra, Spain., Cruz Melguizo S; Department of Gynecology and Obstetrics, Hospital Universitario Puerta de Hierro de Majadahonda, Madrid, Spain., Martínez-Pérez O; Department of Gynecology and Obstetrics, Hospital Universitario Puerta de Hierro de Majadahonda, Madrid, Spain.
Jazyk: angličtina
Zdroj: Reproductive biomedicine online [Reprod Biomed Online] 2022 Jan; Vol. 44 (1), pp. 127-130. Date of Electronic Publication: 2021 Sep 20.
DOI: 10.1016/j.rbmo.2021.09.010
Abstrakt: Research Question: Is there an association between SARS-CoV-2 infection and first-trimester miscarriage?
Design: This multicentre prospective study included a cohort of women with first-trimester miscarriages registered consecutively by seven Spanish hospitals where universal PCR screening for SARS-CoV-2 infection was implemented with both miscarriages and deliveries. The incidence of SARS-CoV-2 infection among women with first-trimester miscarriages was compared with the rate registered in women on admission to the delivery ward within the same time frame using a mixed-effects Poisson regression analysis, considering 'hospital' as random effect. The characteristics of SARS-CoV-2 positive and negative patients who miscarried were compared through two-sided univariable analyses.
Results: A total of 301 miscarriages were registered, 11 (3.7%) to SARS-CoV-2 infected and 290 to non-infected women. In the same time frame as the miscarriages, 1936 deliveries were registered, 44 [2.3%] of them were SARS-CoV-2 infected. No differences in terms of SARS-CoV-2 infection incidence were observed between infected miscarriages and infected deliveries (P = 0.233). Regarding the differences observed between miscarriages in SARS-CoV-2 positive and negative women, more inevitable miscarriages occurred in the group of infected women (36.4% versus 16.5% in non-infected women; P = 0.004), and there was greater surgical management of miscarriages (27.3% versus 8.2% in non-infected women; P = 0.036), probably in line with the greater number of inevitable miscarriages observed in this group.
Conclusions: No association between SARS-CoV-2 infection and risk of first-trimester miscarriage was observed; however, the type of miscarriage seems to differ between SARS-CoV-2 positive and negative women, with inevitable miscarriage being more frequent among infected women.
(Copyright © 2021 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: