Acute hyperglycemia does not affect central respiratory chemoreflex responsiveness to CO 2 in healthy humans.

Autor: Marullo AL; Department of Biology, Faculty of Science and Technology, Mount Royal University, Calgary, Alberta, Canada., Bird JD; Department of Biology, Faculty of Science and Technology, Mount Royal University, Calgary, Alberta, Canada., Ciorogariu-Ivan AM; Department of Biology, Faculty of Science and Technology, Mount Royal University, Calgary, Alberta, Canada., Boulet LM; Centre for Heart, Lung, and Vascular Health, School of Health and Exercise Sciences, University of British Colombia Okanagan, Kelowna, BC, Canada., Strzalkowski NDJ; Department of Biology, Faculty of Science and Technology, Mount Royal University, Calgary, Alberta, Canada., Day TA; Department of Biology, Faculty of Science and Technology, Mount Royal University, Calgary, Alberta, Canada. Electronic address: tday@mtroyal.ca.
Jazyk: angličtina
Zdroj: Respiratory physiology & neurobiology [Respir Physiol Neurobiol] 2022 Feb; Vol. 296, pp. 103803. Date of Electronic Publication: 2021 Oct 12.
DOI: 10.1016/j.resp.2021.103803
Abstrakt: The central respiratory chemoreceptor complex (CCRC) is comprised of brainstem neurons and surrounding interoceptors, which collectively increase ventilation in response to elevated brainstem tissue CO 2 /[H + ] (i.e., central chemoreflex; CCR). The extent that the CCRC detects/responds to other metabolically related chemostimuli is unknown. We aimed to test the effects of acute oral glucose ingestion on CCR reactivity in heathy human participants (n = 38). We instrumented participants with a pneumotachometer (minute ventilation) and a gas sample line connected to a dual gas analyzer (pressure of end-tidal CO 2 ). Following a baseline (BL) period and capillary blood [glucose] (BG) sample, fasted (F) participants underwent a modified hyperoxic rebreathing test to assess CCR reactivity. Participants then consumed a 75 g standard glucose beverage (glucose loaded; GL). Following 30-min, they underwent a second BL, BG sample and hyperoxic rebreathing test. BG and metabolic rate were higher in GL, confirming the metabolic stimulus. However, the ventilatory recruitment threshold and the CCR responses were unchanged between F and GL states.
(Copyright © 2021 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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