Prospective Study of Low- and Standard-dose Chest CT for Pulmonary Nodule Detection: A Comparison of Image Quality, Size Measurements and Radiation Exposure.

Autor: Hu QJ; Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China., Liu YW; Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China., Chen C; Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China., Kang SC; Department of Radiology, Shenzhen Maternity & Child Healthcare Hospital, Southern Medical University, Shenzhen, 518028, China., Sun ZY; Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China., Wang YJ; Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China., Xiang M; Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China., Xia LM; Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China., Guan HX; Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. hxguan@tjh.tjmu.edu.cn.
Jazyk: angličtina
Zdroj: Current medical science [Curr Med Sci] 2021 Oct; Vol. 41 (5), pp. 966-973. Date of Electronic Publication: 2021 Oct 15.
DOI: 10.1007/s11596-021-2433-z
Abstrakt: Objective: To comprehensively and accurately analyze the out-performance of low-dose chest CT (LDCT) vs. standard-dose CT (SDCT).
Methods: The image quality, size measurements and radiation exposure for LDCT and SDCT protocols were evaluated. A total of 117 patients with extra-thoracic malignancies were prospectively enrolled for non-enhanced CT scanning using LDCT and SDCT protocols. Three experienced radiologists evaluated subjective image quality independently using a 5-point score system. Nodule detection efficiency was compared between LDCT and SDCT based on nodule characteristics (size and volume). Radiation metrics and organ doses were analyzed using Radimetrics.
Results: The images acquired with the LDCT protocol yielded comparable quality to those acquired with the SDCT protocol. The sensitivity of LDCT for the detection of pulmonary nodules (n=650) was lower than that of SDCT (n=660). There was no significant difference in the diameter and volume of pulmonary nodules between LDCT and SDCT (for BMI <22 kg/m 2 , 4.37 vs. 4.46 mm, and 43.66 vs. 46.36 mm 3 ; for BMI ≥22 kg/m 2 , 4.3 vs. 4.41 mm, and 41.66 vs. 44.86 mm 3 ) (P>0.05). The individualized volume CT dose index (CTDI vol ), the size specific dose estimate and effective dose were significantly reduced in the LDCT group compared with the SDCT group (all P<0.0001). This was especially true for dose-sensitive organs such as the lung (for BMI <22 kg/m 2 , 2.62 vs. 12.54 mSV, and for BMI ≥22 kg/m 2 , 1.62 vs. 9.79 mSV) and the breast (for BMI <22 kg/m 2 , 2.52 vs. 10.93 mSV, and for BMI ≥22 kg/m 2 , 1.53 vs. 9.01 mSV) (P<0.0001).
Conclusion: These results suggest that with the increases in image noise, LDCT and SDCT exhibited a comparable image quality and sensitivity. The LDCT protocol for chest scans may reduce radiation exposure by about 80% compared to the SDCT protocol.
(© 2021. Huazhong University of Science and Technology.)
Databáze: MEDLINE
Externí odkaz: