GLP-1: 10-year follow-up after Roux-en-Y gastric bypass.

Autor: Carvalho C; Department of Internal Medicine, School of Medical Sciences, PO, University of Campinas-UNICAMP, Campinas, SP, 13083-970, Brazil. carvalhopcami@yahoo.com.br., de Souza AL; Department of Internal Medicine, School of Medical Sciences, University of Campinas-UNICAMP, Campinas, SP, Brazil., Batista GA; Department of Internal Medicine, School of Medical Sciences, University of Campinas-UNICAMP, Campinas, SP, Brazil., Duran LFT; Department of Internal Medicine, School of Medical Sciences, University of Campinas-UNICAMP, Campinas, SP, Brazil., Fernandes DP; Department of Internal Medicine, School of Medical Sciences, University of Campinas-UNICAMP, Campinas, SP, Brazil., Molina VBC; Department of Internal Medicine, School of Medical Sciences, University of Campinas-UNICAMP, Campinas, SP, Brazil., Gonçalves R; Department of Internal Medicine, School of Medical Sciences, University of Campinas-UNICAMP, Campinas, SP, Brazil., Giorgetti JS; Department of Internal Medicine, School of Medical Sciences, University of Campinas-UNICAMP, Campinas, SP, Brazil., Chaim EA; Surgery Department, School of Medical Sciences, University of Campinas-UNICAMP, Campinas, SP, Brazil., Alegre SM; Department of Internal Medicine, School of Medical Sciences, University of Campinas-UNICAMP, Campinas, SP, Brazil.
Jazyk: angličtina
Zdroj: Langenbeck's archives of surgery [Langenbecks Arch Surg] 2022 Mar; Vol. 407 (2), pp. 559-568. Date of Electronic Publication: 2021 Oct 14.
DOI: 10.1007/s00423-021-02341-3
Abstrakt: Purpose: Glucagon-like peptide-1 (GLP-1) is a hormone widely studied in the short-term postoperative follow-up of Roux-en-Y gastric bypass due to its elevation and association with improvement of the glucose metabolism, but there are few studies in 10 years after RYGB follow-up with the same patient.
Methods: Twenty morbidity obesity patients were submitted to RYGB; these patients were divided into two groups: normal glucose-tolerant morbidly obese patients (NGT) 11 patients and abnormal glucose metabolism morbidly obese patients (AGM) 9 patients. Oral glucose tolerance test (OGTT) was done during four different periods: T1 (first evaluation), T2 (pre-surgery), T3 (9 months after surgery) and T4 (10 years after surgery).
Results: Groups were matched for age and gender, and as NGT and AGM had BMI of 46.31 ± 5.03 kg/m 2 and 50.87 ± 10.31 kg/m 2. After 10 years of RYGB, they were obesity grade I with BMI for NGT 32.45 ± 4.99 kg/m 2 and AGM 34.85 ± 4.46 kg/m 2 . Plasma glucose levels decreased NGT group at T4 period had a significant reduction at 120 min after OGTT for NGT 55.49 ± 17.15 mg/dL (p˂0.001). Insulin levels changed from T1 to T4 for the NGT group. GLP-1 curves were statistically different between the NGT and AGM groups. The AGM group had a higher mean for GLP-1 secretion at T4 period and at 30 min of OGTT 63.85 ± 37.98 pmol/L when compared to NGT 50.73 ± 24.82 pmol/L with AGM > NGT with p˂0.001.
Conclusion: Evaluation of the same patient during 4 different periods shows that, even with weight regain, after 10-years of RYGB high levels of GLP-1 remained which can be associated with metabolic improvement especially at the NGT group.
(© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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