Evaluation of Severity of Illness Scores in the Pediatric ECMO Population.

Autor:	Pinto VL; Department of Pediatrics, Baylor College of Medicine, Houston, TX, United States., Guffey D; Institute for Clinical and Translational Research, Baylor College of Medicine, Houston, TX, United States., Loftis L; Department of Pediatrics, Baylor College of Medicine, Houston, TX, United States., Bembea MM; Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, United States., Spinella PC; Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, United States., Hanson SJ; Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI, United States.
Jazyk:	angličtina
Zdroj:	Frontiers in pediatrics [Front Pediatr] 2021 Sep 28; Vol. 9, pp. 698120. Date of Electronic Publication: 2021 Sep 28 (Print Publication: 2021).
DOI:	10.3389/fped.2021.698120
Abstrakt:	Though commonly used for adjustment of risk, severity of illness and mortality risk prediction scores, based on the first 24 h of intensive care unit (ICU) admission, have not been validated in the pediatric extracorporeal membrane oxygenation (ECMO) population. We aimed to determine the association of Pediatric Index of Mortality 2 (PIM2), Pediatric Risk of Mortality Score III (PRISM III) and Pediatric Logistic Organ Dysfunction (PELOD) scores with mortality in pediatric patients on ECMO. This was a retrospective cohort study of children ≤18 years of age included in the Pediatric ECMO Outcomes Registry (PEDECOR) from 2014 to 2018. Logistic regression and Receiver Operating Characteristics (ROC) curves were used to calculate the area under the curve (AUC) to evaluate association of mortality with the scores. Of the 655 cases, 289 (44.1%) did not survive until hospital discharge. AUCs for PIM2, PRISM III, and PELOD predicting mortality were 0.52, 0.52, and 0.51 respectively. PIM2, PRISM III, and PELOD scores are not associated with odds of mortality for pediatric patients receiving ECMO. These scores for a general pediatric ICU population should not be used for prognostication or risk stratification of a select population such as ECMO patients. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2021 Pinto, Guffey, Loftis, Bembea, Spinella and Hanson.)
Databáze:	MEDLINE
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