Opposite response of blood vessels in the retina to 6° head-down tilt and long-duration microgravity.

Autor:	Taibbi G; Department of Ophthalmology and Visual Sciences, The University of Texas Medical Branch at Galveston, Galveston, TX, USA., Young M; NASA Johnson Space Center, Houston, TX, USA., Vyas RJ; Mori Associates, Ames Research Center, NASA, Moffett Field, Mountain View, CA, USA., Murray MC; Blue Marble Space Institute of Science, Space Biology Division, Space Technology Mission Directorate, Ames Research Center, NASA, Moffett Field, Mountain View, CA, USA., Lim S; Blue Marble Space Institute of Science, Space Biology Division, Space Technology Mission Directorate, Ames Research Center, NASA, Moffett Field, Mountain View, CA, USA., Predovic M; Blue Marble Space Institute of Science, Space Biology Division, Space Technology Mission Directorate, Ames Research Center, NASA, Moffett Field, Mountain View, CA, USA., Jacobs NM; Blue Marble Space Institute of Science, Space Biology Division, Space Technology Mission Directorate, Ames Research Center, NASA, Moffett Field, Mountain View, CA, USA., Askin KN; National Space Biomedical Research Institute, Ames Research Center, NASA, Moffett Field, Mountain View, CA, USA., Mason SS; Aegis Aerospace, Inc. Houston, Houston, TX, USA., Zanello SB; KBR, NASA Johnson Space Center, Houston, TX, USA., Vizzeri G; Department of Ophthalmology and Visual Sciences, The University of Texas Medical Branch at Galveston, Galveston, TX, USA., Theriot CA; KBR, NASA Johnson Space Center, Houston, TX, USA.; Department of Preventive Medicine and Community Health, The University of Texas Medical Branch, Galveston, TX, USA., Parsons-Wingerter P; Low Gravity Exploration Technology, Research and Engineering Directorate, John Glenn Research Center, NASA, Cleveland, OH, USA. patriciaparsonsw@gmail.com.
Jazyk:	angličtina
Zdroj:	NPJ microgravity [NPJ Microgravity] 2021 Oct 14; Vol. 7 (1), pp. 38. Date of Electronic Publication: 2021 Oct 14.
DOI:	10.1038/s41526-021-00165-5
Abstrakt:	The Spaceflight Associated Neuro-ocular Syndrome (SANS), associated with the headward fluid shifts incurred in microgravity during long-duration missions, remains a high-priority health and performance risk for human space exploration. To help characterize the pathophysiology of SANS, NASA's VESsel GENeration Analysis (VESGEN) software was used to map and quantify vascular adaptations in the retina before and after 70 days of bed rest at 6-degree Head-Down Tilt (HDT), a well-studied microgravity analog. Results were compared to the retinal vascular response of astronauts following 6-month missions to the International Space Station (ISS). By mixed effects modeling, the trends of vascular response were opposite. Vascular density decreased significantly in the 16 retinas of eight astronauts and in contrast, increased slightly in the ten retinas of five subjects after HDT (although with limited significance). The one astronaut retina diagnosed with SANS displayed the greatest vascular loss. Results suggest that microgravity is a major variable in the retinal mediation of fluid shifts that is not reproduced in this HDT bed rest model. (© 2021. This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply.)
Databáze:	MEDLINE
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