Changes in porcine nutrient transport physiology in response to Ascaris suum infection.
Autor: | Koehler S; Institute for Parasitology, Centre for Infection Medicine, University of Veterinary Medicine Hannover, Hanover, Germany., Springer A; Institute for Parasitology, Centre for Infection Medicine, University of Veterinary Medicine Hannover, Hanover, Germany., Issel N; Institute for Physiology and Cell Biology, University of Veterinary Medicine Hannover, Hanover, Germany., Klinger S; Institute for Physiology and Cell Biology, University of Veterinary Medicine Hannover, Hanover, Germany., Strube C; Institute for Parasitology, Centre for Infection Medicine, University of Veterinary Medicine Hannover, Hanover, Germany., Breves G; Institute for Physiology and Cell Biology, University of Veterinary Medicine Hannover, Hanover, Germany. Gerhard.Breves.iR@tiho-hannover.de. |
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Jazyk: | angličtina |
Zdroj: | Parasites & vectors [Parasit Vectors] 2021 Oct 14; Vol. 14 (1), pp. 533. Date of Electronic Publication: 2021 Oct 14. |
DOI: | 10.1186/s13071-021-05029-1 |
Abstrakt: | Background: The roundworm Ascaris suum is one of the parasites with the greatest economic impact on pig farming. In this context, lower weight gain is hypothesized to be due to decreased nutrient absorption. This study aims at characterizing the effects of A. suum infection on intestinal nutrient transport processes and potential molecular mechanisms. Methods: Three groups of six piglets each were infected orally (10,000 embryonated A. suum eggs) in a single dose ("single infection"). Another three groups were infected orally (1000 embryonated eggs) for 10 consecutive days ("trickle infection"). Animals were necropsied 21, 35 and 49 days post-infection (dpi). Three groups served as respective controls. The Ussing chamber technique was applied for the functional characterization of small intestinal tissues [short-circuit currents (I Results: Peptide- and alanine-induced changes in I Conclusions: In contrast to the current hypothesis, these results indicate that the nutrient deprivation induced by A. suum cannot be explained by transcriptional or expression changes alone and requires further studies. (© 2021. The Author(s).) |
Databáze: | MEDLINE |
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