Telomerase-Positive Somatic Tissues of Honeybee Queens (Apis mellifera) Display No DNA Replication.
| Autor: | Koubová J; Institute of Entomology, Biology Centre of the Czech Academy of Sciences, České Budějovice, Czechia.; Faculty of Science, University of South Bohemia, České Budějovice, Czechia., Čapková Frydrychová R; Institute of Entomology, Biology Centre of the Czech Academy of Sciences, České Budějovice, Czechia.; Faculty of Science, University of South Bohemia, České Budějovice, Czechia. |
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| Jazyk: | angličtina |
| Zdroj: | Cytogenetic and genome research [Cytogenet Genome Res] 2021; Vol. 161 (8-9), pp. 470-475. Date of Electronic Publication: 2021 Oct 14. |
| DOI: | 10.1159/000518888 |
| Abstrakt: | Telomere biology is closely linked to the process of aging. The restoration of telomere length by maintaining telome-rase activity in certain cell types of human adults allows for the proliferative capacity of the cells and preserves the regeneration potential of the tissue. The absence of telome-rase, that leads to telomere attrition and irreversible cell cycle arrest in most somatic cells, acts as a protective mechanism against uncontrolled cancer growth. Nevertheless, there have been numerous studies indicating noncanonical functions of telomerase besides those involved in telomere lengthening. Eusocial insects serve as a great system for aging research. This is because eusocial reproductives, such as queens and kings, have a significantly extended lifespan compared to nonreproductive individuals of the same species. We report that the somatic tissues of honeybee queens (Apis mellifera) are associated with upregulated telomerase activity; however, this upregulation does not fully correlate with the rate of DNA replication in the tissues. This indicates a noncanonical role of telomerase in the somatic tissues of honeybee queens. (© 2021 S. Karger AG, Basel.) |
| Databáze: | MEDLINE |
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