Recruitment and inhibitory action of hippocampal axo-axonic cells during behavior.

Autor:	Dudok B; Department of Neurosurgery, Stanford University, Stanford, CA 94305, USA. Electronic address: bdudok@stanford.edu., Szoboszlay M; Department of Neuroscience, Columbia University, New York, NY 10027, USA., Paul A; Department of Neural and Behavioral Sciences, Penn State College of Medicine, Hershey, PA 17033, USA; Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, NY 11724, USA., Klein PM; Department of Neurosurgery, Stanford University, Stanford, CA 94305, USA., Liao Z; Department of Neuroscience, Columbia University, New York, NY 10027, USA., Hwaun E; Department of Neurosurgery, Stanford University, Stanford, CA 94305, USA., Szabo GG; Department of Neurosurgery, Stanford University, Stanford, CA 94305, USA., Geiller T; Department of Neuroscience, Columbia University, New York, NY 10027, USA., Vancura B; Department of Neuroscience, Columbia University, New York, NY 10027, USA., Wang BS; Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, NY 11724, USA., McKenzie S; Department of Neurosciences, University of New Mexico, Albuquerque, NM 87131, USA; NYU Neuroscience Institute, New York University, New York, NY 10016, USA., Homidan J; Department of Neurosurgery, Stanford University, Stanford, CA 94305, USA., Klaver LMF; School of Neuroscience, Virginia Tech, Blacksburg, VA 24061, USA., English DF; NYU Neuroscience Institute, New York University, New York, NY 10016, USA; School of Neuroscience, Virginia Tech, Blacksburg, VA 24061, USA., Huang ZJ; Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, NY 11724, USA; Department of Neurobiology, Duke University School of Medicine, Durham, NC 27710, USA., Buzsáki G; NYU Neuroscience Institute, New York University, New York, NY 10016, USA., Losonczy A; Department of Neuroscience, Columbia University, New York, NY 10027, USA; Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY 10027, USA., Soltesz I; Department of Neurosurgery, Stanford University, Stanford, CA 94305, USA.
Jazyk:	angličtina
Zdroj:	Neuron [Neuron] 2021 Dec 01; Vol. 109 (23), pp. 3838-3850.e8. Date of Electronic Publication: 2021 Oct 13.
DOI:	10.1016/j.neuron.2021.09.033
Abstrakt:	The axon initial segment of hippocampal pyramidal cells is a key subcellular compartment for action potential generation, under GABAergic control by the "chandelier" or axo-axonic cells (AACs). Although AACs are the only cellular source of GABA targeting the initial segment, their in vivo activity patterns and influence over pyramidal cell dynamics are not well understood. We achieved cell-type-specific genetic access to AACs in mice and show that AACs in the hippocampal area CA1 are synchronously activated by episodes of locomotion or whisking during rest. Bidirectional intervention experiments in head-restrained mice performing a random foraging task revealed that AACs inhibit CA1 pyramidal cells, indicating that the effect of GABA on the initial segments in the hippocampus is inhibitory in vivo. Finally, optogenetic inhibition of AACs at specific track locations induced remapping of pyramidal cell place fields. These results demonstrate brain-state-specific dynamics of a critical inhibitory controller of cortical circuits. Competing Interests: Declaration of interests The authors declare no competing interests. (Copyright © 2021 The Author(s). Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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