Focused ultrasound stimulation on meibomian glands for the treatment of evaporative dry eye.

Autor: Lu G; Roski Eye Institute, 5116Dry Eye Center of Excellence, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.; Department of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA., Gollapudi S; Roski Eye Institute, 5116Dry Eye Center of Excellence, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA., Li R; Roski Eye Institute, 5116Dry Eye Center of Excellence, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.; Department of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA., Pfeiffer ML; Roski Eye Institute, 5116Dry Eye Center of Excellence, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA., Mehta P; Roski Eye Institute, 5116Dry Eye Center of Excellence, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA., Jiang L; Roski Eye Institute, 5116Dry Eye Center of Excellence, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.; Department of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA., Hamm-Alvarez S; Roski Eye Institute, 5116Dry Eye Center of Excellence, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.; Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, CA 90033, USA., Humayun M; Roski Eye Institute, 5116Dry Eye Center of Excellence, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.; Department of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA.; USC Ginsburg Institute for Biomedical Therapeutics, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA., Zhou Q; Roski Eye Institute, 5116Dry Eye Center of Excellence, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.; Department of Biomedical Engineering, University of Southern California, Los Angeles, CA 90089, USA., Zhang-Nunes SX; Roski Eye Institute, 5116Dry Eye Center of Excellence, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Jazyk: angličtina
Zdroj: Experimental biology and medicine (Maywood, N.J.) [Exp Biol Med (Maywood)] 2022 Mar; Vol. 247 (6), pp. 519-526. Date of Electronic Publication: 2021 Oct 14.
DOI: 10.1177/15353702211052035
Abstrakt: Current treatments for meibomian gland dysfunction have several limitations, creating a necessity for other advanced treatment options. The purpose of this study is to determine the effectiveness of focused ultrasound stimulation for the treatment of dry eye disease caused by meibomian gland dysfunction. An in vivo study of nine Dutch Belted rabbits was conducted with focused ultrasound stimulation of the meibomian glands. A customized line-focused ultrasonic transducer was designed for treatment. Fluorescein imaging, Schirmer's test, and Lipiview II ocular interferometer were used to quantify outcomes from three aspects: safety, tear production, and lipid layer thickness. Both tear secretion and lipid layer thickness improved following ultrasound treatment. Five to 10 min after the ultrasound treatment, the mean values of lipid layer thickness increased from 55.33 ± 11.15 nm to 95.67 ± 22.77 nm ( p  < 0.05), while the mean values measured with the Schirmer's test increased from 2.0 ± 2.3 to 7.2 ± 4.3 ( p  < 0.05). Positive effects lasted more than three weeks. Adverse events such as redness, swelling, and mild burn, occurred in two rabbits in preliminary experiments when the eyelids sustained a temperature higher than 42°C. No serious adverse events were found. The results suggest that ultrasound stimulation of meibomian glands can improve both tear production and lipid secretion. Ultimately, ultrasound stimulation has the potential to be an option for the treatment of evaporative dry eye disease caused by meibomian gland dysfunction.
Databáze: MEDLINE
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