Genomic characterization and epidemiology of an emerging SARS-CoV-2 variant in Delhi, India.

Autor: Dhar MS; National Centre for Disease Control, Delhi, India., Marwal R; National Centre for Disease Control, Delhi, India., Vs R; National Centre for Disease Control, Delhi, India., Ponnusamy K; National Centre for Disease Control, Delhi, India., Jolly B; CSIR-Institute of Genomics and Integrative Biology, New Delhi, India.; Academy for Scientific and Innovative Research, Ghaziabad, India., Bhoyar RC; CSIR-Institute of Genomics and Integrative Biology, New Delhi, India., Sardana V; CSIR-Institute of Genomics and Integrative Biology, New Delhi, India.; Academy for Scientific and Innovative Research, Ghaziabad, India., Naushin S; CSIR-Institute of Genomics and Integrative Biology, New Delhi, India.; Academy for Scientific and Innovative Research, Ghaziabad, India., Rophina M; CSIR-Institute of Genomics and Integrative Biology, New Delhi, India.; Academy for Scientific and Innovative Research, Ghaziabad, India., Mellan TA; Medical Research Council (MRC) Centre for Global Infectious Disease Analysis, Jameel Institute, School of Public Health, Imperial College London, London, UK., Mishra S; Medical Research Council (MRC) Centre for Global Infectious Disease Analysis, Jameel Institute, School of Public Health, Imperial College London, London, UK., Whittaker C; Medical Research Council (MRC) Centre for Global Infectious Disease Analysis, Jameel Institute, School of Public Health, Imperial College London, London, UK., Fatihi S; CSIR-Institute of Genomics and Integrative Biology, New Delhi, India.; Academy for Scientific and Innovative Research, Ghaziabad, India., Datta M; National Centre for Disease Control, Delhi, India., Singh P; National Centre for Disease Control, Delhi, India., Sharma U; National Centre for Disease Control, Delhi, India., Ujjainiya R; CSIR-Institute of Genomics and Integrative Biology, New Delhi, India.; Academy for Scientific and Innovative Research, Ghaziabad, India., Bhatheja N; CSIR-Institute of Genomics and Integrative Biology, New Delhi, India., Divakar MK; CSIR-Institute of Genomics and Integrative Biology, New Delhi, India.; Academy for Scientific and Innovative Research, Ghaziabad, India., Singh MK; National Centre for Disease Control, Delhi, India., Imran M; CSIR-Institute of Genomics and Integrative Biology, New Delhi, India.; Academy for Scientific and Innovative Research, Ghaziabad, India., Senthivel V; CSIR-Institute of Genomics and Integrative Biology, New Delhi, India.; Academy for Scientific and Innovative Research, Ghaziabad, India., Maurya R; CSIR-Institute of Genomics and Integrative Biology, New Delhi, India.; Academy for Scientific and Innovative Research, Ghaziabad, India., Jha N; CSIR-Institute of Genomics and Integrative Biology, New Delhi, India., Mehta P; CSIR-Institute of Genomics and Integrative Biology, New Delhi, India., A V; CSIR-Institute of Genomics and Integrative Biology, New Delhi, India.; Academy for Scientific and Innovative Research, Ghaziabad, India., Sharma P; CSIR-Institute of Genomics and Integrative Biology, New Delhi, India.; Academy for Scientific and Innovative Research, Ghaziabad, India., Vr A; CSIR-Institute of Genomics and Integrative Biology, New Delhi, India.; Academy for Scientific and Innovative Research, Ghaziabad, India., Chaudhary U; National Centre for Disease Control, Delhi, India., Soni N; National Centre for Disease Control, Delhi, India., Thukral L; CSIR-Institute of Genomics and Integrative Biology, New Delhi, India.; Academy for Scientific and Innovative Research, Ghaziabad, India., Flaxman S; Department of Mathematics, Imperial College London, London, UK., Bhatt S; Medical Research Council (MRC) Centre for Global Infectious Disease Analysis, Jameel Institute, School of Public Health, Imperial College London, London, UK.; Section of Epidemiology, Department of Public Health, University of Copenhagen, Copenhagen, Denmark., Pandey R; CSIR-Institute of Genomics and Integrative Biology, New Delhi, India.; Academy for Scientific and Innovative Research, Ghaziabad, India., Dash D; CSIR-Institute of Genomics and Integrative Biology, New Delhi, India.; Academy for Scientific and Innovative Research, Ghaziabad, India., Faruq M; CSIR-Institute of Genomics and Integrative Biology, New Delhi, India.; Academy for Scientific and Innovative Research, Ghaziabad, India., Lall H; National Centre for Disease Control, Delhi, India., Gogia H; National Centre for Disease Control, Delhi, India., Madan P; National Centre for Disease Control, Delhi, India., Kulkarni S; National Centre for Disease Control, Delhi, India., Chauhan H; National Centre for Disease Control, Delhi, India., Sengupta S; CSIR-Institute of Genomics and Integrative Biology, New Delhi, India.; Academy for Scientific and Innovative Research, Ghaziabad, India., Kabra S; National Centre for Disease Control, Delhi, India., Gupta RK; Department of Medicine, Cambridge Institute of Therapeutic Immunology and Infectious Disease (CITIID), University of Cambridge, Cambridge, UK.; Africa Health Research Institute, KwaZulu-Natal, South Africa., Singh SK; National Centre for Disease Control, Delhi, India., Agrawal A; CSIR-Institute of Genomics and Integrative Biology, New Delhi, India.; Academy for Scientific and Innovative Research, Ghaziabad, India., Rakshit P; National Centre for Disease Control, Delhi, India., Nandicoori V, Tallapaka KB, Sowpati DT, Thangaraj K, Bashyam MD, Dalal A, Sivasubbu S, Scaria V, Parida A, Raghav SK, Prasad P, Sarin A, Mayor S, Ramakrishnan U, Palakodeti D, Seshasayee ASN, Bhat M, Shouche Y, Pillai A, Dikid T, Das S, Maitra A, Chinnaswamy S, Biswas NK, Desai AS, Pattabiraman C, Manjunatha MV, Mani RS, Arunachal Udupi G, Abraham P, Atul PV, Cherian SS
Jazyk: angličtina
Zdroj: Science (New York, N.Y.) [Science] 2021 Nov 19; Vol. 374 (6570), pp. 995-999. Date of Electronic Publication: 2021 Oct 14.
DOI: 10.1126/science.abj9932
Abstrakt: Delhi, the national capital of India, experienced multiple severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreaks in 2020 and reached population seropositivity of >50% by 2021. During April 2021, the city became overwhelmed by COVID-19 cases and fatalities, as a new variant, B.1.617.2 (Delta), replaced B.1.1.7 (Alpha). A Bayesian model explains the growth advantage of Delta through a combination of increased transmissibility and reduced sensitivity to immune responses generated against earlier variants (median estimates: 1.5-fold greater transmissibility and 20% reduction in sensitivity). Seropositivity of an employee and family cohort increased from 42% to 87.5% between March and July 2021, with 27% reinfections, as judged by increased antibody concentration after a previous decline. The likely high transmissibility and partial evasion of immunity by the Delta variant contributed to an overwhelming surge in Delhi.
Databáze: MEDLINE
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