Presence and clinical impact of human herpesvirus-6 infection in patients with moderate to critical coronavirus disease-19.

Autor: Lino K; Multiuser Laboratory for Research Support in Nephrology and Medical Sciences, Faculty of Medicine, Federal Fluminense University, Niterói, Rio de Janeiro, Brazil.; Postgraduation Program in Medical Sciences, Faculty of Medicine, Federal Fluminense University, Niterói, Rio de Janeiro, Brazil., Alves LS; Multiuser Laboratory for Research Support in Nephrology and Medical Sciences, Faculty of Medicine, Federal Fluminense University, Niterói, Rio de Janeiro, Brazil.; Postgraduation Program in Pathology, Faculty of Medicine, Federal Fluminense University, Niterói, Rio de Janeiro, Brazil., Raposo JV; Laboratory of Molecular Virology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil., Medeiros T; Multiuser Laboratory for Research Support in Nephrology and Medical Sciences, Faculty of Medicine, Federal Fluminense University, Niterói, Rio de Janeiro, Brazil.; Postgraduation Program in Pathology, Faculty of Medicine, Federal Fluminense University, Niterói, Rio de Janeiro, Brazil., Souza CF; Multiuser Laboratory for Research Support in Nephrology and Medical Sciences, Faculty of Medicine, Federal Fluminense University, Niterói, Rio de Janeiro, Brazil.; Postgraduation Program in Medical Sciences, Faculty of Medicine, Federal Fluminense University, Niterói, Rio de Janeiro, Brazil., Silva AAD; Multiuser Laboratory for Research Support in Nephrology and Medical Sciences, Faculty of Medicine, Federal Fluminense University, Niterói, Rio de Janeiro, Brazil.; Department of Pathology, Faculty of Medicine, Federal Fluminense University, Niterói, Rio de Janeiro, Brazil.; Postgraduation Program in Pathology, Faculty of Medicine, Federal Fluminense University, Niterói, Rio de Janeiro, Brazil., de Paula VS; Laboratory of Molecular Virology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil., Almeida JR; Multiuser Laboratory for Research Support in Nephrology and Medical Sciences, Faculty of Medicine, Federal Fluminense University, Niterói, Rio de Janeiro, Brazil.; Department of Clinical Medicine, Faculty of Medicine, Federal Fluminense University, Niterói, Rio de Janeiro, Brazil.; Postgraduation Program in Medical Sciences, Faculty of Medicine, Federal Fluminense University, Niterói, Rio de Janeiro, Brazil.
Jazyk: angličtina
Zdroj: Journal of medical virology [J Med Virol] 2022 Mar; Vol. 94 (3), pp. 1212-1216. Date of Electronic Publication: 2021 Oct 19.
DOI: 10.1002/jmv.27392
Abstrakt: Human herpesvirus-6 (HHV-6) may cause serious diseases in immunocompromised individuals. SARS-CoV-2/HHV-6 coinfection has been emphasized in previous works, mostly case reports, small series, or epidemiological studies, but few are known about its real clinical outcomes. Here we present a real-world pilot study aiming to understand the frequency and the clinical impact of HHV-6 coinfection in moderate to critically ill patients hospitalized due to COVID-19. SARS-CoV-2 and HHV-6 were evaluated in nasopharyngeal samples at the hospital admission of suspected COVID-19 patients. From 173 consecutive cases, 60 were SARS-CoV-2 positive and 13/60 (21.7%) were HHV-6 positive after identified as the HHV-6B species by a Sanger sequencing. The SARS-CoV-2+/HHV-6+ group was younger but not significant for cardiovascular diseases, diabetes, obesity, and cancer, but significant among therapeutic immunosuppressed patients (as systemic lupus erythematosus and kidney transplant patients). In the medical records, only sparse data on cutaneous or neurological manifestations were found. Biochemical and hematological data showed only a trend towards hyperferritinemic status and lymphopenia. In conclusion, despite the impressive high frequency of HHV-6 coinfection in SARS-CoV-2 positive cases, it did not impact general mortality. We suggest larger future prospective studies to better elucidate the influence of HHV-6 reactivation in cases of COVID-19, designed to specific assessment of clinical outcomes and viral reactivation mechanisms.
(© 2021 Wiley Periodicals LLC.)
Databáze: MEDLINE
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